Trial reportClinical journal of the American Society of Nephrology : CJASN2013
Association of BP variability with mortality among African Americans with CKD.
Trial report in Clinical journal of the American Society of Nephrology : CJASN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Blood Pressure Variability and the Progression of Chronic Kidney Disease: a Systematic Review and Meta-Analysis.Journal of general internal medicine · 2023Pooled it
- Cardiovascular disease risk factors in chronic kidney disease: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Blood pressure variability and cardiovascular disease: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2016Pooled it
- Visit-to-visit variability of blood pressure and cardiovascular disease and all-cause mortality: a systematic review and meta-analysis.Hypertension (Dallas, Tex. : 1979) · 2014Pooled it
- Blood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT.Journal of clinical hypertension (Greenwich, Conn.) · 2018Trial
- Influence of fixed-dose combination perindopril/amlodipine on target organ damage in patients with arterial hypertension with and without ischemic heart disease (results of EPHES trial).Vascular health and risk management · 2018Trial
- Medication adherence and visit-to-visit variability of systolic blood pressure in African Americans with chronic kidney disease in the AASK trial.Journal of human hypertension · 2016Trial
- Visit-to-Visit Variability of Blood Pressure and Coronary Heart Disease, Stroke, Heart Failure, and Mortality: A Cohort Study.Annals of internal medicine · 2015Trial
- Clinical impact of proteinuria and blood pressure variability on long-term outcomes after percutaneous coronary intervention.Scientific reports · 2026Observational
- Blood Pressure Variability and End-Stage Kidney Disease Among Individuals With Type 2 Diabetes: A Nationwide Cohort Study.Journal of diabetes · 2025Article
- Visit-to-Visit Systolic Blood Pressure Variability and Risk of Ischemic and Hemorrhagic Stroke.Medicina (Kaunas, Lithuania) · 2025Article
- Blood Pressure Variability in Clinical Practice: Past, Present and the Future.Journal of the American Heart Association · 2023Review
- Blood pressure variability and the development of hypertensive organ damage in the general population.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Association Between Systolic Blood Pressure Variability and Major Adverse Cardiovascular Events in Korean Patients With Chronic Kidney Disease: Findings From KNOW-CKD.Journal of the American Heart Association · 2022Article
- Pathophysiologically based antihypertensive pharmacotherapeutics rationality, efficacy and safety in Sub Saharan African Nations - A review.International journal of cardiology. Cardiovascular risk and prevention · 2021Review
- Visit-to-visit variability of blood pressure and cardiovascular events among the working-age population in Japan: findings from the Japan Epidemiology Collaboration on Occupational Health Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Changes in pre-dialysis blood pressure variability in the first year of dialysis associate with mortality in European hemodialysis patients: a retrospective cohort study on behalf of the MONDO Initiative.Journal of human hypertension · 2021Article
- Association of Blood Pressure Variability and Diuretics With Cardiovascular Events in Patients With Chronic Kidney Disease Stages 1-5.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Clinical implication of visit-to-visit blood pressure variability.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Review
- Visit-to-visit blood pressure variability in children and adolescents with renal disease.Clinical and experimental nephrology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesIncreased systolic BP visit-to-visit variability (SBV) may be associated with higher overall mortality and cardiovascular events. However, few studies have examined these associations in patients with CKD, and the relation of SBV with CKD progression and ESRD has not been shown. This study analyzed the association of SBV with overall mortality, cardiovascular mortality, cardiovascular events, and renal events among individuals enrolled in the African American Study of Kidney Disease (AASK) trial. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was a prospective observational study of 908 participants during the trial phase of the AASK study, with at least 1 year of BP measurements available and followed for 3-6.4 years. SBV was calculated as the SD of the systolic pressure from five visits occurring 3-12 months after randomization. The association of SBV with risk of overall mortality, cardiovascular mortality, a composite of fatal and nonfatal cardiovascular events, and a composite of renal events was assessed using proportional hazards regression and adjusting for multiple potential confounders.
resultsGreater SBV was associated with higher overall mortality. The adjusted hazard ratio (95% confidence interval) was 2.82 (1.14-6.95) comparing the highest with lowest tertile of SBV. A similar comparison revealed that greater SBV was also associated with cardiovascular mortality (adjusted hazard ratio, 4.91; 1.12-21.50). SBV was associated with both the cardiovascular renal composite endpoints in unadjusted but not adjusted analyses.
conclusionsIn African Americans with CKD, SBV is strongly and independently associated with overall and cardiovascular mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.