ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adults.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Effects of blood-flow restriction on biomarkers of myogenesis in response to resistance exercise.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2017Trial
- Effects of a One-Year Physical Activity Program on Serum C-Terminal Agrin Fragment (CAF) Concentrations among Mobility-Limited Older Adults.The journal of nutrition, health & aging · 2015Trial
- Mitochondrial quality control measures, systemic inflammation, and lower-limb muscle power in older adults: a PROMPT secondary analysis.The journal of nutrition, health & aging · 2024Article
- Fish Oil Supplement Mitigates Muscle Injury In Vivo and In Vitro: A Preliminary Report.Nutrients · 2024Article
- Inflammatory pathway communication with skeletal muscle-Does aging play a role? A topical review of the current evidence.Physiological reports · 2024Review
- Review
- Recovery from Resistance Exercise in Older Adults: A Systematic Scoping Review.Sports medicine - open · 2023Article
- Benefits of Eccentric Training with Emphasis on Demands of Daily Living Activities and Feasibility in Older Adults: A Literature Review.International journal of environmental research and public health · 2023Review
- Expression of tissue remodelling, inflammation- and angiogenesis-related factors after eccentric exercise in humans.Molecular biology reports · 2021Article
- Article
- Exercise-Induced Muscle Damage and Recovery in Young and Middle-Aged Males with Different Resistance Training Experience.Sports (Basel, Switzerland) · 2019Article
- The role of mechanobiology in progression of rotator cuff muscle atrophy and degeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Review
- Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging.Journal of the American Medical Directors Association · 2017Article
- Age and sex differences in human skeletal muscle fibrosis markers and transforming growth factor-β signaling.European journal of applied physiology · 2017Article
- Chronic Eccentric Exercise and the Older Adult.Sports medicine (Auckland, N.Z.) · 2015Review
- Human neuromuscular structure and function in old age: A brief review.Journal of sport and health science · 2013Article
- Aging, functional capacity and eccentric exercise training.Aging and disease · 2013Review
- The effects of aerobic and anaerobic exercises on circulating soluble-Klotho and IGF-I in young and elderly adults and in CAD patients.Journal of circulating biomarkersReview
- Functional recovery from eccentric injury is maintained in sarcopenic mouse muscle.JCSM rapid communicationsArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Repair of skeletal muscle after injury is a key aspect of maintaining proper musculoskeletal function. Studies have suggested that regenerative processes, including myogenesis and angiogenesis, are impaired during advanced age, but evidence from humans is limited. This study aimed to compare active muscle regeneration between healthy young and older adults. We evaluated changes in clinical, biochemical, and immunohistochemical indices of muscle regeneration at precisely 2 (T2) and 7 (T3) days following acute muscle injury. Men and women, aged 18-30 and ≥70 years, matched for gender and body mass index, performed 150 unilateral, eccentric contractions of the plantar flexors at 110% of one repetition maximum. Data were analyzed using analysis of covariance, adjusted for gender, habitual physical activity, and baseline level of the outcome. A total of 30 young (n = 15; 22.5 ± 3.7 yr) and older (n = 15; 75.8 ± 5.0 yr) adults completed the study. Following muscle injury, force production declined 16% and 14% in young and older adults, respectively, by T2 and in each group, returned to 93% of baseline strength by T3. Despite modest differences in the pattern of response, postinjury changes in intramuscular concentrations of myogenic growth factors and number of myonuclear (4',6-diamidino-2-phenylindole+ and paired box 7+) cells were largely similar between groups. Likewise, postinjury changes in serum and intramuscular indices of inflammation (e.g., TNF-α and monocyte chemoattractant protein-1) and angiogenesis (e.g., VEGF and kinase insert domain receptor) did not differ significantly between groups. These findings suggest that declines in physical activity and increased co-morbidity may contribute to age-related impairments in active muscle regeneration rather than aging per se.
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Registered trials
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