ArticleClinical cancer research : an official journal of the American Association for Cancer Research2013
Elevated TNFR1 and serotonin in bone metastasis are correlated with poor survival following bone metastasis diagnosis for both carcinoma and sarcoma primary tumors.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Artificial intelligence applied to musculoskeletal oncology: a systematic review.Skeletal radiology · 2022Pooled it
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- Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach.Cell reports methods · 2022Article
- Laser Capture Proteomics: spatial tissue molecular profiling from the bench to personalized medicine.Expert review of proteomics · 2021Review
- Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment.Journal of translational medicine · 2018Article
- Proteomic Analysis Reveals Autophagy as Pro-Survival Pathway Elicited by Long-Term Exposure with 5-Azacitidine in High-Risk Myelodysplasia.Frontiers in pharmacology · 2017Article
- Translational research in diagnosis and management of soft tissue tumours.Cancer imaging : the official publication of the International Cancer Imaging Society · 2016Review
- The Role of Prolactin in Bone Metastasis and Breast Cancer Cell-Mediated Osteoclast Differentiation.Journal of the National Cancer Institute · 2016Article
- Persistent CD49d engagement in circulating CLL cells: a role for blood-borne ligands?Leukemia · 2016Article
- Immunocapture strategies in translational proteomics.Expert review of proteomics · 2016Review
- Interaction between TNFR1 and TNFR2 dominates the clinicopathologic features of human hypopharyneal carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- IL-32α suppresses colorectal cancer development via TNFR1-mediated death signaling.Oncotarget · 2015Article
- Tissue and serum IGFBP7 protein as biomarker in high-grade soft tissue sarcoma.American journal of cancer research · 2015Article
- High CerS5 expression levels associate with reduced patient survival and transition from apoptotic to autophagy signalling pathways in colorectal cancer.The journal of pathology. Clinical research · 2015Article
- Targeting integrin α6 stimulates curative-type bone metastasis lesions in a xenograft model.Molecular cancer therapeutics · 2014Article
- Mapping protein signal pathway interaction in sarcoma bone metastasis: linkage between rank, metalloproteinases turnover and growth factor signaling pathways.Clinical & experimental metastasis · 2014Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeThere is an urgent need for therapies that will reduce the mortality of patients with bone metastasis. In this study, we profiled the protein signal pathway networks of the human bone metastasis microenvironment. The goal was to identify sets of interacting proteins that correlate with survival time following the first diagnosis of bone metastasis. EXPERIMENTAL
designUsing Reverse Phase Protein Microarray technology, we measured the expression of 88 end points in the bone microenvironment of 159 bone metastasis tissue samples derived from patients with primary carcinomas and sarcomas.
resultsMetastases originating from different primary tumors showed similar levels of cell signaling across tissue types for the majority of proteins analyzed, suggesting that the bone microenvironment strongly influences the metastatic tumor signaling profiles. In a training set (72 samples), TNF receptor 1, alone (P = 0.0013) or combined with serotonin (P = 0.0004), TNFα (P = 0.0214), and RANK (P = 0.0226), was associated with poor survival, regardless of the primary tumor of origin. Results were confirmed by (i) analysis of an independent validation set (71 samples) and (ii) independent bioinformatic analysis using a support vector machine learning model. Spearman rho analysis revealed a highly significant number of interactions intersecting with ERα S118, serotonin, TNFα, RANKL, and matrix metalloproteinase in the bone metastasis signaling network, regardless of the primary tumor. The interaction network pattern was significantly different in the short versus long survivors.
conclusionsTNF receptor 1 and neuroendocrine-regulated protein signal pathways seem to play an important role in bone metastasis and may constitute a novel drug-targetable mechanism of seed-soil cross talk in bone metastasis.
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