Moving towards early clinical trials for amyloid-targeted therapy in Alzheimer's disease.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.

1. Comparative effects of different exercise modalities on cognitive domains in older adults: a Bayesian network meta-analysis and meta-regression.Frontiers in nutrition · 2026
   Pooled it
2. The Amyloid-β Pathway in Alzheimer's Disease.Molecular psychiatry · 2021
   Pooled it
3. An Insight into the Recent Advancement in Anti-Alzheimer's Potential of Indole Derivatives and their SAR Study.Current topics in medicinal chemistry · 2025
   Review
4. Apolar Extracts of St. John's Wort Alleviate the Effects of β-Amyloid Toxicity in Early Alzheimer's Disease.International journal of molecular sciences · 2024
   Article
5. Identifying healthy individuals with Alzheimer's disease neuroimaging phenotypes in the UK Biobank.Communications medicine · 2023
   Article
6. Decoding the Roles of Amyloid-β (1-42)'s Key Oligomerization Domains toward Designing Epitope-Specific Aggregation Inhibitors.JACS Au · 2023
   Article
7. The lateral entorhinal cortex is a hub for local and global dysfunction in early Alzheimer's disease states.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
   Article
8. Designing the next-generation clinical care pathway for Alzheimer's disease.Nature aging · 2022
   Review
9. Dual Task Performance Is Associated with Amyloidosis in Cognitively Healthy Adults.The journal of prevention of Alzheimer's disease · 2022
   Article
10. The relationship of semantic intrusions to different etiological subtypes of MCI and cognitively healthy older adults.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021
    Article
11. Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers.International journal of molecular sciences · 2020
    Article
12. The effects of insulin and insulin-like growth factor I on amyloid precursor protein phosphorylation in in vitro and in vivo models of Alzheimer's disease.Neurobiology of disease · 2019
    Review
13. Heat Shock Protein Inspired Nanochaperones Restore Amyloid-β Homeostasis for Preventative Therapy of Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Article
14. Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic.Nature reviews. Neurology · 2018
    Review
15. Editorial: Turning Point towards Blood Biomarker-Guided Targeted Therapy for Precision Medicine in Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2018
    Article
16. Internet Searches and Their Relationship to Cognitive Function in Older Adults: Cross-Sectional Analysis.Journal of medical Internet research · 2017
    Article
17. The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017
    Review
18. NIA-AA staging of preclinical Alzheimer disease: discordance and concordance of CSF and imaging biomarkers.Neurobiology of aging · 2016
    Article
19. Reference tissue normalization in longitudinal (18)F-florbetapir positron emission tomography of late mild cognitive impairment.Alzheimer's research & therapy · 2016
    Article
20. What can triumphs and tribulations from drug research in Alzheimer's disease tell us about the development of psychotropic drugs in general?The lancet. Psychiatry · 2015
    Review

Corrections and comments

• Comment on
  Sting of Alzheimer's failures offset by upcoming prevention trials.2012

Authors and funding

3 authors at 3 institutions in 3 countries.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as