ArticleInternational journal of molecular sciences2013
Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster.
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 69 citations in OpenAlex.
- Mechanisms and Manifestations of Ligand Bias in Signaling: Focus on Receptor Tyrosine Kinases.Chemical reviews · 2026Review
- Temporal Dynamics of Extracellular Signal-Regulated Kinase Phosphorylation and Associated Signaling Genes During Embryonic Development in Bombyx mori.Archives of insect biochemistry and physiology · 2026Article
- FGF and BMP pathway genes are expressed in segmentally iterated domains during segmentation of germ layers in a tardigrade.bioRxiv : the preprint server for biology · 2025Article
- Article
- Developmental exposure of antibiotics shortens life span and induces teratogenicity inToxicology reports · 2024Article
- MIGGRI: A multi-instance graph neural network model for inferring gene regulatory networks for Drosophila from spatial expression images.PLoS computational biology · 2023Article
- Review
- Devo-Aging: Intersections Between Development and Aging.GeroScience · 2023Review
- Drosophila FGFR/Htl signaling shapes embryonic glia to phagocytose apoptotic neurons.Cell death discovery · 2023Article
- FGF signaling promotes spreading of fat body precursors necessary for adult adipogenesis in Drosophila.PLoS biology · 2023Article
- Review
- Spatiotemporal sensitivity of mesoderm specification to FGFR signalling in the Drosophila embryo.Scientific reports · 2021Article
- Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis in Drosophila.Nature cell biology · 2021Article
- Genetic interactions regulate hypoxia tolerance conferred by activating Notch in excitatory amino acid transporter 1-positive glial cells in Drosophila melanogaster.G3 (Bethesda, Md.) · 2021Article
- The vascular niche controls Drosophila hematopoiesis via fibroblast growth factor signaling.eLife · 2021Article
- Synapse development and maturation at the drosophila neuromuscular junction.Neural development · 2020Review
- Collective Migrations ofGenetics · 2020Review
- What lies beneath: Hydra provides cnidarian perspectives into the evolution of FGFR docking proteins.Development genes and evolution · 2020Article
- FGF signaling directs myotube guidance by regulating Rac activity.Development (Cambridge, England) · 2020Article
- FGF receptors are required for proper axonal branch targeting in Drosophila.Molecular brain · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Intercellular signalling via growth factors plays an important role in controlling cell differentiation and cell movements during the development of multicellular animals. Fibroblast Growth Factor (FGF) signalling induces changes in cellular behaviour allowing cells in the embryo to move, to survive, to divide or to differentiate. Several examples argue that FGF signalling is used in multi-step morphogenetic processes to achieve and maintain a transitional state of the cells required for the control of cell fate. In the genetic model Drosophila melanogaster, FGF signalling via the receptor tyrosine kinases Heartless (Htl) and Breathless (Btl) is particularly well studied. These FGF receptors affect gene expression, cell shape and cell-cell interactions during mesoderm layer formation, caudal visceral muscle (CVM) formation, tracheal morphogenesis and glia differentiation. Here, we will address the current knowledge of the biological functions of FGF signalling in the fly on the tissue, at a cellular and molecular level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.