ArticleScientific reports2013
Selective modulation of cell response on engineered fractal silicon substrates.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Nano-Topography Enhanced Topological-Cell-Analysis in Radiation-Therapy.Advanced healthcare materials · 2025Review
- The role of elasticity on adhesion and clustering of neurons on soft surfaces.Communications biology · 2024Article
- Article
- Complex Tumor Spheroid Formation and One-Step Cancer-Associated Fibroblasts Purification from Hepatocellular Carcinoma Tissue Promoted by Inorganic Surface Topography.Nanomaterials (Basel, Switzerland) · 2021Article
- Cell Theranostics on Mesoporous Silicon Substrates.Pharmaceutics · 2020Article
- Cortical-like mini-columns of neuronal cells on zinc oxide nanowire surfaces.Scientific reports · 2019Article
- Relating the rate of growth of metal nanoparticles to cluster size distribution in electroless deposition.Nanoscale advances · 2019Article
- Evaluation of highly carbonated hydroxyapatite bioceramic implant coatings with hierarchical micro-/nanorod topography optimized for osseointegration.International journal of nanomedicine · 2018Article
- Modeling the Improved Visual Acuity Using Photodiode Based Retinal Implants Featuring Fractal Electrodes.Frontiers in neuroscience · 2018Article
- Nano-topography Enhances Communication in Neural Cells Networks.Scientific reports · 2017Article
- Topography design concept of a tissue engineering scaffold for controlling cell function and fate through actin cytoskeletal modulation.Tissue engineering. Part B, Reviews · 2014Review
- Investigation of early cell-surface interactions of human mesenchymal stem cells on nanopatterned β-type titanium-niobium alloy surfaces.Interface focus · 2014Article
- Characterizing nanoscale topography of the aortic heart valve basement membrane for tissue engineering heart valve scaffold design.Tissue engineering · 2006Article
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Authors and funding
8 authors.
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Abstract
A plethora of work has been dedicated to the analysis of cell behavior on substrates with ordered topographical features. However, the natural cell microenvironment is characterized by biomechanical cues organized over multiple scales. Here, randomly rough, self-affinefractal surfaces are generated out of silicon,where roughness Ra and fractal dimension Df are independently controlled. The proliferation rates, the formation of adhesion structures, and the morphology of 3T3 murine fibroblasts are monitored over six different substrates. The proliferation rate is maximized on surfaces with moderate roughness (Ra ~ 40 nm) and large fractal dimension (Df ~ 2.4); whereas adhesion structures are wider and more stable on substrates with higher roughness (Ra ~ 50 nm) and lower fractal dimension (Df ~ 2.2). Higher proliferation occurson substrates exhibiting densely packed and sharp peaks, whereas more regular ridges favor adhesion. These results suggest that randomly roughtopographies can selectively modulate cell behavior.
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