ArticleIranian journal of basic medical sciences2012
Mutation Analysis of TP53 Tumor Suppressor Gene in Colorectal Cancer in Patients from Iran (Kerman Province).
Article in Iranian journal of basic medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Association betweenIranian journal of public health · 2025Review
- Association of MTHFR C677T variant genotype with serum folate and Vit B12 in Iranian patients with colorectal cancer or adenomatous polyps.BMC medical genomics · 2021Article
- PKM2 in carcinogenesis and oncotherapy.Oncotarget · 2017Review
- Rising rates of colorectal cancer among younger Iranians: is diet to blame?Current oncology (Toronto, Ont.) · 2017Article
- Colorectal cancer in iran: molecular epidemiology and screening strategies.Journal of cancer epidemiology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesP53 is an important tumor suppressor, which is mutated in later stages of many cancers and leads to resistance to chemotherapy. The aim of this study was to reveal mutations of TP53 in colorectal cancer in Kerman province. MATERIALS AND
methodsA total of Forty-three colon cancer specimens as paraffin block or fresh tissues, which passed stage IIIA, were selected. Three exons 5, 7 and 8 of P53 were amplified by PCR technique and sequenced directly.
resultsThe results showed two deletions at codon 140 and 142 in one tumor sample. GAT→AAT mutation at codon 184, and CGG→TGG mutation at codon 248 were seen in some tumor samples. Some mutations were also observed in middle of intron 7 in some tumor or normal tissues.
conclusionSome of those patients with mutation in P53 gene had metastasis in other organs. Therefore, genetic test before chemotherapy is helpful for successful treatment.
Indexed as
Identifiers
23492839PMC3586867W2188394403What OpenQuestion holds
Registered trials
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