ArticleCell death & disease2013
Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum.
Article in Cell death & disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
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- The role of astrocytes in epileptic disorders.Physiological reports · 2022Review
- Organization of the ventricular zone of the cerebellum.Frontiers in cellular neuroscience · 2022Review
- Olig2 knockdown alleviates hypoxic-ischemic brain damage in newborn rats.Histology and histopathology · 2021Article
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- Peculiar protrusions along tanycyte processes face diverse neural and nonneural cell types in the hypothalamic parenchyma.The Journal of comparative neurology · 2021Article
- HIFα Regulates Developmental Myelination Independent of Autocrine Wnt Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Progenies of NG2 glia: what do we learn from transgenic mouse models ?Neural regeneration research · 2021Article
- Four main therapeutic keys for Parkinson's disease: A mini review.Iranian journal of basic medical sciences · 2019Review
- Chronic inflammation and apoptosis propagate in ischemic cerebellum and heart of non-human primates.Oncotarget · 2017Article
- The Role of the Oligodendrocyte Lineage in Acute Brain Trauma.Neurochemical research · 2017Review
- Oligodendroglial defects during quakingviable cerebellar development.Developmental neurobiology · 2016Article
- Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition.eLife · 2016Article
- Voluntary Exercise Induces Astrocytic Structural Plasticity in the Globus Pallidus.Frontiers in cellular neuroscience · 2016Article
- The p38α mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS.Cell death & disease · 2015Article
- Phenotype overlap in glial cell populations: astroglia, oligodendroglia and NG-2(+) cells.Frontiers in neuroanatomy · 2015Article
- Finding degrees of separation: experimental approaches for astroglial and oligodendroglial cell isolation and genetic targeting.Journal of neuroscience methods · 2014Review
- Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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Authors and funding
5 authors at 1 institution in 2 countries.
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Abstract
NG2 (nerve/glial antigen2)-expressing cells represent the largest population of postnatal progenitors in the central nervous system and have been classified as oligodendroglial progenitor cells, but the fate and function of these cells remain incompletely characterized. Previous studies have focused on characterizing these progenitors in the postnatal and adult subventricular zone and on analyzing the cellular and physiological properties of these cells in white and gray matter regions in the forebrain. In the present study, we examine the types of neural progeny generated by NG2 progenitors in the cerebellum by employing genetic fate mapping techniques using inducible Cre-Lox systems in vivo with two different mouse lines, the Plp-Cre-ER(T2)/Rosa26-EYFP and Olig2-Cre-ER(T2)/Rosa26-EYFP double-transgenic mice. Our data indicate that Olig2/Plp-positive NG2 cells display multipotential properties, primarily give rise to oligodendroglia but, surprisingly, also generate Bergmann glia, which are specialized glial cells in the cerebellum. The NG2+ cells also give rise to astrocytes, but not neurons. In addition, we show that glutamate signaling is involved in distinct NG2+ cell-fate/differentiation pathways and plays a role in the normal development of Bergmann glia. We also show an increase of cerebellar oligodendroglial lineage cells in response to hypoxic-ischemic injury, but the ability of NG2+ cells to give rise to Bergmann glia and astrocytes remains unchanged. Overall, our study reveals a novel Bergmann glia fate of Olig2/Plp-positive NG2 progenitors, demonstrates the differentiation of these progenitors into various functional glial cell types, and provides significant insights into the fate and function of Olig2/Plp-positive progenitor cells in health and disease.
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