ArticleHuman molecular genetics2013
Predicting the impact of diet and enzymopathies on human small intestinal epithelial cells.
Article in Human molecular genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 74 citations in OpenAlex.
- Virtual Colon: spatiotemporal modeling of metabolic interactions in a computational colonic environment.mSystems · 2026Article
- Investigating intestinal epithelium metabolic dysfunction in celiac disease using personalized genome-scale models.BMC medicine · 2025Article
- In silico dietary interventions using whole-body metabolic models reveal sex-specific and differential dietary risk profiles for metabolic syndrome.Frontiers in physiology · 2025Article
- Community metabolic modeling of host-microbiota interactions through multi-objective optimization.iScience · 2024Article
- Integrating Omics Data in Genome-Scale Metabolic Modeling: A Methodological Perspective for Precision Medicine.Metabolites · 2023Review
- Towards applications of genome-scale metabolic model-based approaches in designing synthetic microbial communities.Quantitative biology (Beijing, China) · 2023Review
- Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes.Cell reports. Medicine · 2022Article
- Metabolic modeling of host-microbe interactions for therapeutics in colorectal cancer.NPJ systems biology and applications · 2022Article
- Whole-body metabolic modelling predicts isoleucine dependency of SARS-CoV-2 replication.Computational and structural biotechnology journal · 2022Article
- A Computational Framework for Studying Gut-Brain Axis in Autism Spectrum Disorder.Frontiers in physiology · 2022Article
- Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species.Scientific reports · 2021Article
- Rare genetic variants affecting urine metabolite levels link population variation to inborn errors of metabolism.Nature communications · 2021Article
- Fibroblast-specific genome-scale modelling predicts an imbalance in amino acid metabolism in Refsum disease.The FEBS journal · 2020Article
- Personalized whole-body models integrate metabolism, physiology, and the gut microbiome.Molecular systems biology · 2020Article
- From bag-of-genes to bag-of-genomes: metabolic modelling of communities in the era of metagenome-assembled genomes.Computational and structural biotechnology journal · 2020Review
- Predicting gastrointestinal drug effects using contextualized metabolic models.PLoS computational biology · 2019Article
- Review
- Constraint-based modeling in microbial food biotechnology.Biochemical Society transactions · 2018Review
- Predicting the murine enterocyte metabolic response to diets that differ in lipid and carbohydrate composition.Scientific reports · 2017Article
- Quantitative systems pharmacology and the personalized drug-microbiota-diet axis.Current opinion in systems biology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small intestinal epithelial cells (sIECs) have a significant share in whole body metabolism as they perform enzymatic digestion and absorption of nutrients. Furthermore, the diet plays a key role in a number of complex diseases including obesity and diabetes. The impact of diet and altered genetic backgrounds on human metabolism may be studied by using computational modeling. A metabolic reconstruction of human sIECs was manually assembled using the literature. The resulting sIEC model was subjected to two different diets to obtain condition-specific metabolic models. Fifty defined metabolic tasks evaluated the functionalities of these models, along with the respective secretion profiles, which distinguished between impacts of different dietary regimes. Under the average American diet, the sIEC model resulted in higher secretion flux for metabolites implicated in metabolic syndrome. In addition, enzymopathies were analyzed in the context of the sIEC metabolism. Computed results were compared with reported gastrointestinal (GI) pathologies and biochemical defects as well as with biomarker patterns used in their diagnosis. Based on our simulations, we propose that (i) sIEC metabolism is perturbed by numerous enzymopathies, which can be used to study cellular adaptive mechanisms specific for such disorders, and in the identification of novel co-morbidities, (ii) porphyrias are associated with both heme synthesis and degradation and (iii) disturbed intestinal gamma-aminobutyric acid synthesis may be linked to neurological manifestations of various enzymopathies. Taken together, the sIEC model represents a comprehensive, biochemically accurate platform for studying the function of sIEC and their role in whole body metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.