Trial reportMedical science monitor : international medical journal of experimental and clinical research2013
Cervical sympathetic block regulates early systemic inflammatory response in severe trauma patients.
Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Effect of ultrasound-guided stellate ganglion block on inflammatory cytokines and postoperative recovery after partial hepatectomy: a randomised clinical trial.BMC anesthesiology · 2024Trial
- Effects of stellate ganglion block on early brain injury in patients with subarachnoid hemorrhage: a randomised control trial.BMC anesthesiology · 2021Trial
- Restoration of gamma-aminobutyric acid homeostasis: A novel approach to alleviating central nervous system injury-associated immunodepression syndrome.Neural regeneration research · 2026Article
- Stellate ganglion block achieves remission of recurrent head-and-neck plaque psoriasis: A case report.The Journal of international medical research · 2026Article
- Towards a nonlinear "neuroimmune gate-model": beyond stellate ganglion block and vagus nerve stimulation.Frontiers in neuroscience · 2026Article
- Neurocardiology - from basics to clinic.World journal of cardiology · 2025Review
- Bilateral Dual Level Cervical Sympathetic Blocks to Treat Post-TBI Sequelae: A Case Report.Case reports in neurological medicine · 2025Article
- Effects of ultrasound-guided stellate ganglion block on intrapulmonary shunt and oxygenation in patients with single-lung ventilation.Frontiers in surgery · 2024Article
- Therapeutic Use of Low-Dose Local Anesthetics in Pain, Inflammation, and Other Clinical Conditions: A Systematic Scoping Review.Journal of clinical medicine · 2023Article
- Stellate Ganglion Block Relieves Long COVID-19 Symptoms in 86% of Patients: A Retrospective Cohort Study.Cureus · 2023Article
- Sympathetic Blocks as a Predictor for Response to Ketamine Infusion in Patients with Complex Regional Pain Syndrome: A Multicenter Study.Pain medicine (Malden, Mass.) · 2023Article
- Short Communication: Stellate Ganglion Blockade for Persistent Olfactory and Gustatory Symptoms Post-COVID-19.Local and regional anesthesia · 2023Article
- Spinal cord stimulation for refractory pericarditis: a case report and a review of the mechanism of action.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- An Approach to Acute SARS-CoV-2 Management with Complementary Neuraltherapeutic Medicine: A Case Report.Clinical medicine insights. Case reports · 2023Article
- Stellate ganglion block reduces inflammation and improves neurological function in diabetic rats during ischemic stroke.Neural regeneration research · 2022Article
- Cervical sympathetic trunk transection alleviates acute lung injury caused by intestinal obstruction via inhibition of phospholipase ABMC anesthesiology · 2022Article
- Stellate ganglion block as an intervention in refractory eosinophilic granulomatosis with polyangiitis: a case report.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Article
- Immune modulation after traumatic brain injury.Frontiers in medicine · 2022Review
- Stellate Ganglion Block Combined with Dexmedetomidine Protects Obese Rats from Lipopolysaccharide-Induced Acute Lung Injury.Journal of healthcare engineering · 2022Article
- Risk Factors of Postoperative Meningitis in Lateral Ventricular Trigone Meningiomas: A Clinical Analysis of 64 Patients.Frontiers in surgery · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis aim of this study was to investigate the effects of one-side cervical sympathetic block on early inflammatory response in severe trauma patients. MATERIAL AND
methodsThirty severe trauma patients with injury severity score (ISS) of 16 to 25 were randomly divided into treatment and control groups (n=15 each). Patients in the treatment group underwent a right-side stellate ganglion block (SGB) using 8 mL 0.75% ropivacaine for 4 times, with the first injection within 12 hr of admission and the other 3 injections were 12 hr, 24 hr and 48 hr later. The same procedures were performed for the control group except that normal saline was injected instead of ropivacaine. Blood was collected before injection and at 6 hr, 24 hr, and 72 hr after the first SGB for serum interleukin (IL)-1beta, IL-4, IL-6, IL-10 and TNF-alpha measurement.
resultsThe concentrations of IL-1beta, IL-6, and TNF-alpha between 24 hr to 72 hr after SGB were all significantly lower than those in the control group (all P values <0.01). However, there was no significant difference in the concentrations of anti-inflammatory IL-4 and IL-10 between treatment and control groups. There was no obvious impact of SGB on breathing and circulation except for a slower heart rate 10 to 50 min after injection (P<0.01).
conclusionsSGB regulates early inflammatory response through inhibition of the proinflammatory cytokines IL-1beta, IL-6, and TNF-alpha during severe trauma. SGB has no impact on the levels of anti-inflammatory cytokines IL-4 and IL-10.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.