ArticleAmerican journal of respiratory and critical care medicine2013
Catch-up alveolarization in ex-preterm children: evidence from (3)He magnetic resonance.
Article in American journal of respiratory and critical care medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Lung volumes, gas transfer and oscillometry after preterm birth: systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Impaired lung function and associated risk factors in children born prematurely: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Bronchopulmonary dysplasia and extremely preterm birth: time for a broader perspective on long-term outcomes.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Lung MRI scoring reveals persistence of emphysema-like changes in lungs of infants born preterm at (pre)school age.ERJ open research · 2025Article
- Changes in lung function in children after pneumonia: a multicenter study.Italian journal of pediatrics · 2025Article
- Pulmonary MRI in Newborns and Children.Journal of magnetic resonance imaging : JMRI · 2025Review
- Enlarged airspaces in the distal lung in adolescents born very preterm as measured by aerosol.BMJ open respiratory research · 2024Article
- Oligohydramnios affects pulmonary functional/structural abnormalities in school-aged children with bronchopulmonary dysplasia.Clinical and experimental pediatrics · 2024Article
- Preterm lung and brain responses to mechanical ventilation and corticosteroids.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Early-Life Weight Status and Risk of Childhood Asthma or Recurrent Wheeze in Preterm and Term Offspring.The journal of allergy and clinical immunology. In practice · 2023Article
- Increasing airway obstruction through life following bronchopulmonary dysplasia: a meta-analysis.ERJ open research · 2023Review
- Prematurity and BPD: what general pediatricians should know.European journal of pediatrics · 2023Review
- Respiratory morbidity in preschool and school-age children born very preterm and its association with parents' health-related quality of life and family functioning.European journal of pediatrics · 2023Article
- Seeing Premature Lung Disease: Hyperpolarized Xe Magnetic Resonance Imaging.American journal of respiratory and critical care medicine · 2023Article
- Image Phenotyping of Preterm-Born Children Using HyperpolarizedAmerican journal of respiratory and critical care medicine · 2023Article
- Long-term expiratory airflow of infants born moderate-late preterm: A systematic review and meta-analysis.EClinicalMedicine · 2022Article
- Development of lung diffusion to adulthood following extremely preterm birth.The European respiratory journal · 2022Article
- Lifelong Lung Sequelae of Prematurity.International journal of environmental research and public health · 2022Review
- Time-Specific Factors Influencing the Development of Asthma in Children.Biomedicines · 2022Review
- What is BPD today and in the next 50 years?American journal of physiology. Lung cellular and molecular physiology · 2021Article
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10 authors.
Funding
Abstract
rationaleHistologic data from fatal cases suggest that extreme prematurity results in persisting alveolar damage. However, there is new evidence that human alveolarization might continue throughout childhood and could contribute to alveolar repair.
objectivesTo examine whether alveolar damage in extreme-preterm survivors persists into late childhood, we compared alveolar dimensions between schoolchildren born term and preterm, using hyperpolarized helium-3 magnetic resonance.
methodsWe recruited schoolchildren aged 10-14 years stratified by gestational age at birth (weeks) to four groups: (1) term-born (37-42 wk; n = 61); (2) mild preterm (32-36 wk; n = 21); (3) extreme preterm (<32 wk, not oxygen dependent at 4 wk; n = 19); and (4) extreme preterm with chronic lung disease (<32 wk and oxygen dependent beyond 4 wk; n = 18). We measured lung function using spirometry and plethysmography. Apparent diffusion coefficient, a surrogate for average alveolar dimensions, was measured by helium-3 magnetic resonance. MEASUREMENTS AND MAIN
resultsThe two extreme preterm groups had a lower FEV1 (P = 0.017) compared with term-born and mild preterm children. Apparent diffusion coefficient was 0.092 cm(2)/second (95% confidence interval, 0.089-0.095) in the term group. Corresponding values were 0.096 (0.091-0.101), 0.090 (0085-0.095), and 0.089 (0.083-0.094) in the mild preterm and two extreme preterm groups, respectively, implying comparable alveolar dimensions across all groups. Results did not change after controlling for anthropometric variables and potential confounders.
conclusionsAlveolar size at school age was similar in survivors of extreme prematurity and term-born children. Because extreme preterm birth is associated with deranged alveolar structure in infancy, the most likely explanation for our finding is catch-up alveolarization.
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