Trial reportPediatric diabetes2013
Pediatric diabetic ketoacidosis, fluid therapy, and cerebral injury: the design of a factorial randomized controlled trial.
Trial report in Pediatric diabetes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01365793 (Fluid Therapy and Cerebral Injury in Pediatric Diabetic Ketoacidosis), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fluid Therapy and Cerebral Injury in Pediatric Diabetic Ketoacidosis
Who cites it
26 citing papers in PubMed, 69 citations in OpenAlex.
- Clinical and Laboratory Predictors of Dehydration Severity in Children With Diabetic Ketoacidosis.Annals of emergency medicine · 2023Trial
- Effects of Fluid Rehydration Strategy on Correction of Acidosis and Electrolyte Abnormalities in Children With Diabetic Ketoacidosis.Diabetes care · 2021Trial
- Cognitive Function Following Diabetic Ketoacidosis in Children With New-Onset or Previously Diagnosed Type 1 Diabetes.Diabetes care · 2020Trial
- Hypertension during Diabetic Ketoacidosis in Children.The Journal of pediatrics · 2020Trial
- Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis.The New England journal of medicine · 2018Trial
- Circulating matrix metalloproteinases in children with diabetic ketoacidosis.Pediatric diabetes · 2017Trial
- Distinct attentional profiles associated with diabetic ketoacidosis and hypoglycemia in pediatric type 1 diabetes: MOXO-CPT assessment.Endocrine · 2026Article
- Diabetic Ketoacidosis: Considerations and Residual Controversies in Management After the 2024 ADA, EASD, JBDS, AACE, and DST Joint ConsensusEndocrine, metabolic & immune disorders drug targets · 2026Review
- Hyperglycemic Crises in Adults With Diabetes: A Consensus Report.Diabetes care · 2024Review
- Hyperglycaemic crises in adults with diabetes: a consensus report.Diabetologia · 2024Article
- Article
- Emergency Department Presentations of Diabetic Ketoacidosis in a Large Cohort of Children.Pediatric diabetes · 2023Article
- Incidence and predictors of mortality in children with diabetic ketoacidosis in the comprehensive specialized referral hospitals of West Amhara Region, Northwest Ethiopia: a retrospective follow-up study.Frontiers in clinical diabetes and healthcare · 2023Article
- A 5-year-old with new-onset diabetes presenting with ketoacidosis, acute pancreatitis, and renal failure.SAGE open medical case reports · 2022Article
- Enroller Experience and Parental Familiarity of Disease Influence Participation in a Pediatric Trial.The western journal of emergency medicine · 2021Article
- The Two-bag System for Intravenous Fluid Management of Children with Diabetic Ketoacidosis: Experience from a Community-Based Hospital.Global pediatric health · 2021Article
- Frequency and Risk Factors of Acute Kidney Injury During Diabetic Ketoacidosis in Children and Association With Neurocognitive Outcomes.JAMA network open · 2020Article
- Homocysteine, interleukin-1β, and fasting blood glucose levels as prognostic markers for diabetes mellitus complicated with cerebral infarction and correlated with carotid intima-media thickness.Experimental and therapeutic medicine · 2020Article
- Article
- Fluid Therapy For Pediatric Patients With Diabetic Ketoacidosis: Current Perspectives.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Treatment protocols for pediatric diabetic ketoacidosis (DKA) vary considerably among centers in the USA and worldwide. The optimal protocol for intravenous (IV) fluid administration is an area of particular controversy, mainly in regard to possible associations between rates of IV fluid infusion and the development of cerebral edema (CE), the most common and the most feared complication of DKA in children. Theoretical concerns about associations between osmotic fluid shifts and CE have prompted recommendations for conservative fluid infusion during DKA. However, recent data suggest that cerebral hypoperfusion may play a role in cerebral injury associated with DKA. Currently, there are no existing data from prospective clinical trials to determine the optimal fluid treatment protocol for pediatric DKA. The Pediatric Emergency Care Applied Research Network FLUID (FLuid therapies Under Investigation in DKA) study is the first prospective randomized trial to evaluate fluid regimens for pediatric DKA. This 13-center nationwide factorial design study will evaluate the effects of rehydration rate and fluid sodium content on neurological status during DKA treatment, the frequency of clinically overt CE and long-term neurocognitive outcomes following DKA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.