ArticleCellular microbiology2013
Cell surface changes in the Candida albicans mitochondrial mutant goa1Δ are associated with reduced recognition by innate immune cells.
Article in Cellular microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 45 citations in OpenAlex.
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- Assessing Complex I (CI) Mitochondrial Subunit Protein Functions in Candida albicans.Methods in molecular biology (Clifton, N.J.) · 2022Article
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- An evolutionarily diverged mitochondrial protein controls biofilm growth and virulence in Candida albicans.PLoS biology · 2021Article
- Deletion of theFrontiers in cellular and infection microbiology · 2021Article
- Mitochondria-Mediated Azole Drug Resistance and Fungal Pathogenicity: Opportunities for Therapeutic Development.Microorganisms · 2020Review
- Inhibition of Respiration of Candida albicans by Small Molecules Increases Phagocytosis Efficacy by Macrophages.mSphere · 2020Article
- The C3HC type zinc-finger protein (ZFC3) interacting with Lon/MAP1 is important for mitochondrial gene regulation, infection hypha development and longevity of Magnaporthe oryzae.BMC microbiology · 2020Article
- Mitochondrial Complex I Core Protein Regulates cAMP Signaling via Phosphodiesterase Pde2 and NAD Homeostasis inFrontiers in microbiology · 2020Article
- Study on the Function of the Inositol Polyphosphate Kinases Kcs1 and Vip1 ofFrontiers in microbiology · 2020Article
- Fungal Mitogenomes: Relevant Features to Planning Plant Disease Management.Frontiers in microbiology · 2020Review
- Unique, Diverged, and Conserved Mitochondrial Functions Influencing Candida albicans Respiration.mBio · 2019Article
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- Alternative Oxidase Promotes Biofilm Formation of Candida albicans.Current medical science · 2018Article
- Exploring and exploiting the connection between mitochondria and the virulence of human pathogenic fungi.Virulence · 2018Review
- Review
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
We have previously characterized several fungal-specific proteins from the human pathogen Candida albicans that either encode subunits of mitochondria Complex I (CI) of the electron transport chain (ETC) or regulate CI activity (Goa1p). Herein, the role of energy production and cell wall gene expression is investigated in the mitochondria mutant goa1Δ. We show that downregulation of cell wall-encoding genes in the goa1Δ results in sensitivity to cell wall inhibitors such as Congo red and Calcofluor white, reduced phagocytosis by a macrophage cell line, reduced recognition by macrophage receptors, and decreased expression of cytokines such as IL-6, IL-10 and IFN-γ. In spite of the reduced recognition by macrophages, the goa1Δ is still killed to the same extent as control strains. We also demonstrate that expression of the epithelial cell receptors E-cadherin and EGFR is also reduced in the presence of goa1Δ. Together, our data demonstrate the importance of mitochondria in the expression of cell wall biomolecules and the interaction of C. albicans with innate immune and epithelial cells. Our underlying premise is thatmitochondrial proteins such as Goa1p and other fungal-specific mitochondrial proteins regulate critical functions in cell growth and in virulence. As such, they remain as valid drug targets for antifungal drug discovery.
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