ArticleNeurogastroenterology and motility2013
Circumferential and functional re-entry of in vivo slow-wave activity in the porcine small intestine.
Article in Neurogastroenterology and motility, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of small intestine pacing parameters for modulation of gut function.Neurogastroenterology and motility · 2023Pooled it
- Electromechanical coupling across the gastroduodenal junction.Acta physiologica (Oxford, England) · 2025Review
- Acupuncture and moxibustion intervention in functional dyspepsia: Gastric and duodenal regulation.Heliyon · 2024Review
- Pacemaking function of two simplified cell models.PloS one · 2022Article
- Improved Visualization of Gastrointestinal Slow Wave Propagation Using a Novel Wavefront-Orientation Interpolation Technique.IEEE transactions on bio-medical engineering · 2018Article
- Effect of bisacodyl on rats with slow transit constipation.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- Progress in Mathematical Modeling of Gastrointestinal Slow Wave Abnormalities.Frontiers in physiology · 2017Review
- Iterative Covariance-Based Removal of Time-Synchronous Artifacts: Application to Gastrointestinal Electrical Recordings.IEEE transactions on bio-medical engineering · 2016Article
- Simultaneous anterior and posterior serosal mapping of gastric slow-wave dysrhythmias induced by vasopressin.Experimental physiology · 2016Article
- Mechanisms of Electrical Activation and Conduction in the Gastrointestinal System: Lessons from Cardiac Electrophysiology.Frontiers in physiology · 2016Review
- Electrophysiological Mechanisms of Gastrointestinal Arrhythmogenesis: Lessons from the Heart.Frontiers in physiology · 2016Review
- A theoretical study of the initiation, maintenance and termination of gastric slow wave re-entry.Mathematical medicine and biology : a journal of the IMA · 2015Article
- Motor patterns of the small intestine explained by phase-amplitude coupling of two pacemaker activities: the critical importance of propagation velocity.American journal of physiology. Cell physiology · 2015Article
- Loss of Interstitial Cells of Cajal and Patterns of Gastric Dysrhythmia in Patients With Chronic Unexplained Nausea and Vomiting.Gastroenterology · 2015Article
- A review of mixing and propulsion of chyme in the small intestine: fresh insights from new methods.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Review
- Multi-channel wireless mapping of gastrointestinal serosal slow wave propagation.Neurogastroenterology and motility · 2015Article
- Effects of gap junction inhibition on contraction waves in the murine small intestine in relation to coupled oscillator theory.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Macrophages in diabetic gastroparesis--the missing link?Neurogastroenterology and motility · 2015Review
- A system and method for online high-resolution mapping of gastric slow-wave activity.IEEE transactions on bio-medical engineering · 2014Article
- Recent progress in gastric arrhythmia: pathophysiology, clinical significance and future horizons.Clinical and experimental pharmacology & physiology · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundSlow-waves modulate the pattern of small intestine contractions. However, the large-scale spatial organization of intestinal slow-wave pacesetting remains uncertain because most previous studies have had limited resolution. This study applied high-resolution (HR) mapping to evaluate intestinal pacesetting mechanisms and propagation patterns in vivo.
methodsHR serosal mapping was performed in anesthetized pigs using flexible arrays (256 electrodes; 32 × 8; 4 mm spacing), applied along the jejunum. Slow-wave propagation patterns, frequencies, and velocities were calculated. Slow-wave initiation sources were identified and analyzed by animation and isochronal activation mapping. KEY
resultsAnalysis comprised 32 recordings from nine pigs (mean duration 5.1 ± 3.9 min). Slow-wave propagation was analyzed, and a total of 26 sources of slow-wave initiation were observed and classified as focal pacemakers (31%), sites of functional re-entry (23%) and circumferential re-entry (35%), or indeterminate sources (11%). The mean frequencies of circumferential and functional re-entry were similar (17.0 ± 0.3 vs 17.2 ± 0.4 cycle min(-1) ; P = 0.5), and greater than that of focal pacemakers (12.7 ± 0.8 cycle min(-1) ; P < 0.001). Velocity was anisotropic (12.9 ± 0.7 mm s(-1) circumferential vs 9.0 ± 0.7 mm s(-1) longitudinal; P < 0.05), contributing to the onset and maintenance of re-entry. CONCLUSIONS & INFERENCES: This study has shown multiple patterns of slow-wave initiation in the jejunum of anesthetized pigs. These results constitute the first description and analysis of circumferential re-entry in the gastrointestinal tract and functional re-entry in the in vivo small intestine. Re-entry can control the direction, pattern, and frequency of slow-wave propagation, and its occurrence and functional significance merit further investigation.
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