ArticleEuropean journal of oral sciences2013
Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis.
Article in European journal of oral sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Age-Related Alterations in SIBLING Proteins and Dentin Micro-Architecture: Morphological and Molecular Associations.Life (Basel, Switzerland) · 2025Article
- DSP and DPP are dispensable for initiation of dentin and enamel mineralization but critical for circumpulpal dentin mineralization.Scientific reports · 2025Article
- Characterization of SIBLING Proteins in the Mineralized Tissues.Dentistry journal · 2022Article
- Phenotype and molecular characterizations of a family with dentinogenesis imperfecta shields type II with a novelAnnals of translational medicine · 2021Article
- Dentine sialophosphoprotein signal in dentineogenesis and dentine regeneration.European cells & materials · 2021Review
- Haploinsufficiency ofFrontiers in physiology · 2020Article
- Protein S100-A7 Derived from Digested Dentin Is a Critical Molecule for Dentin Pulp Regeneration.Cells · 2019Article
- The functional significance of dentin sialoprotein-phosphophoryn and dentin sialoprotein.International journal of oral science · 2018Review
- Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null mice.PloS one · 2018Article
- Effects of Btbd7 knockdown on the proliferation of human dental pulp cells and expression of Dspp.International journal of clinical and experimental pathology · 2018Article
- DENTAL ENAMEL FORMATION AND IMPLICATIONS FOR ORAL HEALTH AND DISEASE.Physiological reviews · 2017Review
- Transgenic expression of dentin phosphoprotein inhibits skeletal development.European journal of histochemistry : EJH · 2016Article
- Article
- Dentin Matrix Proteins in Bone Tissue Engineering.Advances in experimental medicine and biology · 2015Review
- Overexpressing the NHJournal of oral biosciences · 2014Article
- Failure to process dentin sialophosphoprotein into fragments leads to periodontal defects in mice.European journal of oral sciences · 2013Article
- Accelerated enamel mineralization in Dspp mutant mice.Matrix biology : journal of the International Society for Matrix BiologyArticle
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Dentin sialophosphoprotein (DSPP) is a large precursor protein that is proteolytically processed into a NH2 -terminal fragment [composed of dentin sialoprotein (DSP) and a proteoglycan form (DSP-PG)] and a COOH-terminal fragment [dentin phosphoprotein (DPP)]. In vitro studies indicate that DPP is a strong initiator and regulator of hydroxyapatite crystal formation and growth, but the role(s) of the NH2 -terminal fragment of DSPP (i.e., DSP and DSP-PG) in dentinogenesis remain unclear. This study focuses on the function of the NH2 -terminal fragment of DSPP in dentinogenesis. Here, transgenic (Tg) mouse lines expressing the NH2 -terminal fragment of DSPP driven by a 3.6-kb type I collagen promoter (Col 1a1) were generated and cross-bred with Dspp null mice to obtain mice that express the transgene but lack the endogenous Dspp (Dspp KO/DSP Tg). We found that dentin from the Dspp KO/DSP Tg mice was much thinner, more poorly mineralized, and remarkably disorganized compared with dentin from the Dspp KO mice. The fact that Dspp KO/DSP Tg mice exhibited more severe dentin defects than did the Dspp null mice indicates that the NH2 -terminal fragment of DSPP may inhibit dentin mineralization or may serve as an antagonist against the accelerating action of DPP and serve to prevent predentin from being mineralized too rapidly during dentinogenesis.
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