Evidence map›Paper›PMID 23489584›Full record

ReviewJournal of the American Academy of Dermatology2013

The skin microbiome: current perspectives and future challenges.

Yiyin Erin Chen, Hensin Tsao

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Journal of the American Academy of Dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03149900 (Exploratory Evaluation of Biomarkers Associated With Treatment Response to Cosentyx), which is not on this map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
16.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03149900 completednot on this mapstarted 2016, after this paper: background citation

Exploratory Evaluation of Biomarkers Associated With Treatment Response to Cosentyx (Secukinumab) in Psoriasis Patients

TypeobservationalSponsorDiamant ThaciRan2016 to 2019Enrolled40ConditionsPsoriasis VulgarisArmsSecukinumab
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 259 citations in OpenAlex.

  1. A systematic review and meta-analysis on Staphylococcus aureus carriage in psoriasis, acne and rosacea.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016
    Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Microbiome dysbiosis and therapeutic restoration in atopic dermatitis.Frontiers in cellular and infection microbiology · 2026
    Review
  7. Pharmaceutical biology · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. The Role of MicroRNA in the Pathogenesis of Atopic Dermatitis.International journal of molecular sciences · 2025
    Review
  14. Article
  15. The sticky situation of human skin.Journal of biosciences · 2025
    Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Yiyin Erin ChenMedical Scientist Training Program, Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts, USA.
Hensin Tsao
Harvard University · USMassachusetts General Hospital · US

Funding

Molecular Risk Assessment in Hereditary MelanomaK24CA149202 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI TSAO, HENSIN · 2010 to 2019
$1.9M
NCI NIH HHS K24 CA149202
6 · The paper itself

Abstract

Complex communities of bacteria, fungi, and viruses thrive on our skin. The composition of these communities depends on skin characteristics, such as sebaceous gland concentration, moisture content, and temperature, as well as on host genetics and exogenous environmental factors. Recent metagenomic studies have uncovered a surprising diversity within these ecosystems and have fostered a new view of commensal organisms as playing a much larger role in immune modulation and epithelial health than previously expected. Understanding microbe-host interactions and discovering the factors that drive microbial colonization will help us understand the pathogenesis of skin diseases and develop new promicrobial and antimicrobial therapeutics.

Indexed as

MetagenomeAnimalsColony Count, MicrobialDermatitis, AtopicHumansImmunity, InnateNucleic Acid Amplification TechniquesRNA, Ribosomal, 16SSkinSkin Diseases, InfectiousSkin NeoplasmsRNA, Ribosomal, 16S

Identifiers

PMID23489584
PMCPMC3686918
OpenAlexW2161899152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.