Trial reportJournal of affective disorders2013
Changes in cognitive versus somatic symptoms of depression and event-free survival following acute myocardial infarction in the Enhancing Recovery In Coronary Heart Disease (ENRICHD) study.
Trial report in Journal of affective disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- The Mental Health-Acute Coronary Syndrome Continuum: Bidirectional Pathophysiological Links and Clinical Implications.Medical sciences (Basel, Switzerland) · 2026Review
- Symptoms that remain after depression treatment in patients with coronary heart disease.Journal of psychosomatic research · 2023Article
- Investigation of the shared molecular mechanisms and hub genes between myocardial infarction and depression.Frontiers in cardiovascular medicine · 2023Article
- Article
- Mechanism and therapeutic strategies of depression after myocardial infarction.Psychopharmacology · 2021Review
- Research progress regarding the diagnosis and treatment of mental stress-induced myocardial ischemia.Anatolian journal of cardiology · 2020Review
- Measurement invariance of the patient health questionnaire-9 (PHQ-9) depression screener in U.S. adults across sex, race/ethnicity, and education level: NHANES 2005-2016.Depression and anxiety · 2019Article
- Psychological and psychopathological sequelae in cardiovascular acute disease.Mental illness · 2018Article
- The heart of the matter: in search of causal effects of depression on somatic diseases.BMC medicine · 2018Article
- The Role of the Myocardial Microvasculature in Mental Stress-Induced Myocardial Ischemia.Clinical cardiology · 2016Review
- Base Rates of Depressive Symptoms in Patients with Coronary Heart Disease: An Individual Symptom Analysis.PloS one · 2016Article
- Changes in Depressive Symptoms and Mortality in Patients With Heart Failure: Effects of Cognitive-Affective and Somatic Symptoms.Psychosomatic medicine · 2015Article
- The predictive value of somatic and cognitive depressive symptoms for cytokine changes in patients with major depression.Neuropsychiatric disease and treatment · 2014Article
- Depressive symptom clusters as predictors of incident coronary artery disease: a 15-year prospective study.Psychosomatic medicine · 2014Article
- Depression as a risk factor for adverse outcomes in coronary heart disease.BMC medicine · 2013Article
- Depression as a non-causal variable risk marker in coronary heart disease.BMC medicine · 2013Article
- The Longitudinal Association of Reduced Vagal Tone With Burnout.Psychosomatic medicineArticle
- Cognitive Function in Heart Failure Is Associated With Nonsomatic Symptoms of Depression But Not Somatic Symptoms.The Journal of cardiovascular nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundRandomized controlled trials focusing on the effects of antidepressant treatment in cardiac patients have found modest effects on depressive symptoms but not on cardiac outcomes. A secondary analysis was conducted on data from the Enhancing Recovery in Coronary Heart Disease trial to assess whether changes in somatic or cognitive depressive symptoms following acute MI predicted event-free survival and whether the results differed per treatment arm (cognitive behavior therapy or care as usual).
methodsPatients who met depression criteria and completed the 6th month depression assessment (n=1254) were included in this study. Measurements included demographic and clinical data and the Beck Depression Inventory at baseline and 6 months. The primary endpoint was a composite of recurrent MI and mortality over 2.4 years (standard deviation=0.9 years).
resultsPositive changes (per 1 point increase) in somatic depressive symptoms (HR: 0.95; 95% CI: 0.92-0.98; p=0.001) but not in cognitive depressive symptoms (HR: 0.98; 95% CI: 0.96-1.01; p=0.19) were related to a reduced risk of recurrent MI and mortality after adjustment for baseline depression scores. There was a trend for an interaction effect between changes in somatic depressive symptoms and the intervention (p=0.08). After controlling for demographic and clinical variables, the association between changes in somatic depressive symptoms and event-free survival remained significant in the intervention arm (HR: 0.93; 95% CI: 0.88-0.98; p=0.01) only. LIMITATIONS: Secondary analyses.
conclusionsChanges in somatic depressive symptoms, and not cognitive symptoms, were related to improved outcomes in the intervention arm, independent of demographic and clinical variables.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.