ArticleBJOG : an international journal of obstetrics and gynaecology2013
Effects of ibuprofen, diclofenac, naproxen, and piroxicam on the course of pregnancy and pregnancy outcome: a prospective cohort study.
Article in BJOG : an international journal of obstetrics and gynaecology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Maternal non-steroidal anti-inflammatory drug exposure during pregnancy and risk of miscarriage: a systematic review and meta-analysis.European journal of clinical pharmacology · 2022Pooled it
- Reducing Exposure Before Birth: An Interrupted Time Series Study of Prenatal Exposure to Fetotoxic Medications Under Risk Management Plans in Canada.Clinical pharmacology and therapeutics · 2026Article
- Genetically Informed Research Designs in Perinatal Pharmacoepidemiology: A Methodological Overview.Drug safety · 2026Review
- First-trimester nonsteroidal anti-inflammatory drugs exposure and risk of major congenital malformations: A retrospective register-based cohort study.PLoS medicine · 2026Article
- Naproxen and Ibuprofen Exposure Alter the Blood-Testis Barrier in a Novel In Vitro Model.International journal of molecular sciences · 2026Article
- Article
- Prevalence and associated factors of self-medication among pregnant women in N'Djamena North District, Chad.The Pan African medical journal · 2026Article
- Lupus nephritis: management challenges during pregnancy.Frontiers in nephrology · 2024Review
- Neonatal and maternal adverse outcomes and exposure to nonsteroidal anti-inflammatory drugs during early pregnancy in South Korea: A nationwide cohort study.PLoS medicine · 2023Article
- Interpreting the Benefit and Risk Data in Between-Drug Comparisons: Illustration of the Challenges Using the Example of Mefenamic Acid versus Ibuprofen.Pharmaceutics · 2022Review
- Pharmacovigilance pregnancy data in a large population of patients with chronic inflammatory disease exposed to certolizumab pegol.Therapeutic advances in musculoskeletal disease · 2022Article
- Association of Prenatal Acetaminophen Exposure Measured in Meconium With Adverse Birth Outcomes in a Canadian Birth Cohort.Frontiers in pediatrics · 2022Article
- Drug related adverse pregnancy outcomes at a tertiary care hospital from the foothills of Himalayas: A Prospective observational study.Journal of family medicine and primary care · 2021Article
- Association between maternal acetaminophen use and adverse birth outcomes in a pregnancy and birth cohort.Pediatric research · 2020Article
- Rheumatologic Medication Use During Pregnancy.Obstetrics and gynecology · 2020Review
- Pain medications during pregnancy: data from the Japan environment and children's study.Journal of anesthesia · 2020Article
- Microengineered human amniotic ectoderm tissue array for high-content developmental phenotyping.Biomaterials · 2019Article
- Pharmacoepidemiologic Evaluation of Birth Defects from Health-Related Postings in Social Media During Pregnancy.Drug safety · 2019Article
- Association Between Meconium Acetaminophen and Childhood Neurocognitive Development in GESTE, a Canadian Cohort Study.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Current concepts in migraine and their relevance to pregnancy.Obstetric medicine · 2018Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo investigate the individual effects of ibuprofen, diclofenac, naproxen, and piroxicam on pregnancy outcome.
designCohort study.
settingNorwegian population. POPULATION: A total of 90 417 women and singleton child pairs.
methodsThe Norwegian Mother and Child Cohort Study and Medical Birth Registry of Norway data sets were used.
main outcome measuresInfant survival, congenital malformations, structural heart defects, neonatal complications, haemorrhage during pregnancy and postpartum, asthma at age of 18 months.
resultsOne or more of the four nonsteroidal anti-inflammatory drugs (NSAIDs) were used by 6511 pregnant women (7.2%). No effect on rates of infant survival, congenital malformation, or structural heart defects was found. The use of ibuprofen in the second trimester was significantly associated with low birthweight (adjusted OR 1.7, 95% CI 1.3-2.3), and ibuprofen use in the second and third trimesters was significantly associated with asthma in 18-month-old children (adjusted OR 1.5, 95% CI 1.2-1.9; adjusted OR 1.5, 95% CI 1.1-2.1). The use of diclofenac in the second trimester was significantly associated with low birthweight (adjusted OR 3.1, 95% CI 1.1-9.0), whereas diclofenac use in the third trimester was significantly associated with maternal vaginal bleeding (adjusted OR 1.8, 95% CI 1.1-3.0). No associations with other neonatal complications were found.
conclusionsThe lack of associations with congenital malformations is reassuring. The significant association between diclofenac and ibuprofen use late in pregnancy, and maternal bleeding and asthma in the child, respectively, is consistent with their pharmacological effects. The increased risk of low birthweight may partly have been caused by underlying inflammatory conditions, and was reassuringly similar to the expected baseline risk of low birthweight.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.