ArticleMedical mycology2013
Galectin-3 plays an important role in protection against disseminated candidiasis.
Article in Medical mycology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 75 citations in OpenAlex.
- Deletion of Galectin-3 Renders Mice Less Susceptible to Candida auris Skin Infection by Enhancing Antifungal Activity of Neutrophils.The Journal of infectious diseases · 2025Article
- Review
- Protective innate immunity againstInfection and immunity · 2024Article
- Review
- The role of galectins in immunity and infection.Nature reviews. Immunology · 2023Review
- Molecular association ofFrontiers in cellular and infection microbiology · 2023Review
- Galectins-1, -3 and -9 Are Present in Breast Milk and Have a Role in Early Life Development.Nutrients · 2022Article
- Galectins as potential therapeutic targets in STIs in the female genital tract.Nature reviews. Urology · 2022Review
- When Is It Appropriate to Take Off the Mask? Signaling Pathways That Regulate ß(1,3)-Glucan Exposure inFrontiers in fungal biology · 2022Article
- Altered expression of genes related to innate antifungal immunity in the absence of galectin-3.Virulence · 2021Article
- Local antifungal immunity in the kidney in disseminated candidiasis.Current opinion in microbiology · 2021Review
- Influence of Galectin-3 on the Innate Immune Response during Experimental Cryptococcosis.Journal of fungi (Basel, Switzerland) · 2021Article
- Article
- Article
- Galectin-3 enhances neutrophil motility and extravasation into the airways during Aspergillus fumigatus infection.PLoS pathogens · 2020Article
- Galectin-3: Roles in Neurodevelopment, Neuroinflammation, and Behavior.Biomolecules · 2020Review
- Utilization of Galectins by Pathogens for Infection.Frontiers in immunology · 2020Review
- Article
- Dysregulated Mucosal Immunity and Associated Pathogeneses in Preterm Neonates.Frontiers in immunology · 2020Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Recent in vitro studies have implicated galectin-3 as an important receptor in host recognition and response to specific Candida species; however, its role in protection against disseminated candidiasis in vivo has not been evaluated. This study investigated the importance of galectin-3 in host defense against systemic infection with the highly virulent species Candida albicans, and the less virulent species, C. parapsilosis. Mice deficient in galectin-3 (gal3-/-) were more susceptible to infection than wild-type (WT) mice. When infected with C. albicans, gal3-/- mice died significantly faster and exhibited a trend towards increased fungal burden and increased abscess formation in infected brains compared to WT mice. When infected with C. parapsilosis, gal3-/- mice had significantly higher renal fungal burdens and abscess formation compared to WT mice. To evaluate whether galectin-3 may contribute to susceptibility to candidiasis in human infants, galectin-3 levels in sera of newborn infants, a patient population uniquely susceptible to infections with both C. albicans and C. parapsilosis, were compared to serum galectin-3 levels of adults. Galectin-3 levels were significantly lower in newborn infant sera compared to adult sera. These data indicate that galectin-3 plays an important role in a murine model of disseminated candidiasis and suggest a potential mechanism of neonatal susceptibility to these infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.