ArticleJournal of the American Chemical Society2013
Pd-catalyzed asymmetric β-hydride elimination en route to chiral allenes.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed.
- Palladium-catalyzed enantioselective β-hydride elimination for the construction of remote stereocenters.Nature communications · 2025Article
- Stereoselective Synthesis of Axially Chiral Allenes and Styrenes via Chiral Phosphoric Acid Catalysis: An Overview.ACS omega · 2024Review
- Stereoselectivity control in Rh-catalyzed β-OH elimination for chiral allene formation.Nature communications · 2023Article
- Pd/Xu-Phos-catalyzed asymmetric elimination of fully substituted enol triflates into axially chiral trisubstituted allenes.Science advances · 2023Article
- Chiral Allenylcarbonyls - Underexploited Building Blocks for Complex Synthesis.Letters in organic chemistry · 2022Article
- Photo and copper dual catalysis for allene syntheses from propargylic derivatives via one-electron process.Nature communications · 2022Article
- Iron-Catalyzed Contrasteric Functionalization of Allenic C(spJournal of the American Chemical Society · 2021Article
- Generation of Axially Chiral Fluoroallenes through a Copper-Catalyzed Enantioselective β-Fluoride Elimination.Journal of the American Chemical Society · 2021Article
- Catalytic asymmetric and stereodivergent oligonucleotide synthesis.Science (New York, N.Y.) · 2021Article
- Palladium-catalyzed allene synthesis enabled by β-hydrogen elimination from spNature communications · 2021Article
- Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies.Nature communications · 2020Article
- Copper(I)-catalyzed diastereo- and enantio-selective construction of optically pure exocyclic allenes.Nature communications · 2020Article
- Photochemical Deracemization of Allenes and Subsequent Chirality Transfer.Angewandte Chemie (International ed. in English) · 2020Article
- Copper Hydride Catalyzed Enantioselective Synthesis of Axially Chiral 1,3-Disubstituted Allenes.Journal of the American Chemical Society · 2019Article
- Catalytic enantioselective construction of axial chirality in 1,3-disubstituted allenes.Nature communications · 2019Article
- Enantiodivergent Synthesis of Allenes by Point-to-Axial Chirality Transfer.Angewandte Chemie (International ed. in English) · 2018Article
- Formation of Chiral Allylic Ethers via an Enantioselective Palladium-Catalyzed Alkenylation of Acyclic Enol Ethers.Journal of the American Chemical Society · 2018Article
- Intramolecular Chirality Transfer [2 + 2] Cycloadditions of Allenoates and Alkenes.Organic letters · 2017Article
- Enantioselective Synthesis of Allenes by Catalytic Traceless Petasis Reactions.Journal of the American Chemical Society · 2017Article
- Palladium-Catalyzed Oxidative Synthesis of α-Acetoxylated Enones from Alkynes.Angewandte Chemie (International ed. in English) · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We wish to report our preliminary results on the discovery and development of a catalytic, asymmetric β-hydride elimination from vinyl Pd(II)-complexes derived from enol triflates to access chiral allenes. To achieve this, we developed a class of chiral phosphite ligands that demonstrate high enantioselectivity, allow access of either allene enantiomer, and are readily synthesized. The methodology is demonstrated on over 20 substrates, and application to the formal asymmetric total synthesis of the natural product, (+)-epibatidine, is also provided.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.