ArticleAmerican journal of public health2013
Opioid agonist treatments and heroin overdose deaths in Baltimore, Maryland, 1995-2009.
Article in American journal of public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07148206 (Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial), which is not on this map. Cited by 129 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial
Who cites it
129 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Medication for opioid use disorder in the Arab World: A systematic review.The International journal on drug policy · 2022Pooled it
- Effects of medication-assisted treatment on mortality among opioids users: a systematic review and meta-analysis.Molecular psychiatry · 2019Pooled it
- Worldwide Prevalence and Trends in Unintentional Drug Overdose: A Systematic Review of the Literature.American journal of public health · 2015Pooled it
- The payer's role in addressing the opioid epidemic: It's more than money.Journal of substance abuse treatment · 2019Trial
- Application of a RE-AIM Evaluation Framework to Test Integration of a Mindfulness Based Parenting Intervention into a Drug Treatment Program.Maternal and child health journal · 2019Trial
- Patient-centered methadone treatment: a randomized clinical trial.Addiction (Abingdon, England) · 2017Trial
- Independent Relationship between Incarceration Factors and Glycemic Control in African Americans with Criminal Legal Involvement and Type 2 Diabetes.Journal of health care for the poor and underserved · 2026Article
- "They should be like penicillin": barriers to the integration of medications for opioid use disorder in specialty treatment programs.Addiction science & clinical practice · 2025Article
- Article
- Medicaid: Increased Patient Access To MOUD In Residential Treatment Associated With Facility Openings And Closures, 2012-22.Health affairs (Project Hope) · 2025Article
- The effect of take-home naloxone kits on opioid-related deaths in Alberta, Canada: An ecological analysis.Canadian journal of public health = Revue canadienne de sante publique · 2025Article
- Retention and dropout from sublingual and extended-release buprenorphine treatment: A comparative analysis of data from a nationally representative sample of commercially-insured people with opioid use disorder in the United States.The International journal on drug policy · 2025Article
- Police Knowledge, Attitudes, and Beliefs About Opioid Addiction Treatment and Harm Reduction: A Survey of Illinois Officers.Journal of drug issues · 2025Article
- The Relationship Between Methadone and Buprenorphine Enrollment and Overdose Prevention and Treatment Behaviors Among a Community Sample of People Who Use Opioids in Baltimore, Maryland.International journal of environmental research and public health · 2025Article
- Medicaid expansion and medications to treat opioid use disorder in outpatient specialty care from 2010 to 2020.Journal of substance use and addiction treatment · 2025Article
- Development, Validity, and Acceptability of the Peer Recovery Coach (PRC) Service Checklist for Medication for Opioid Use Disorder (MOUD) Support.Substance use & misuse · 2025Article
- Virtual Primary Care for People With Opioid Use Disorder: Scoping Review of Current Strategies, Benefits, and Challenges.Journal of medical Internet research · 2024Article
- "Tethered to this ball and chain": Women's perspectives on bodily agency within opioid treatment programs.The International journal on drug policy · 2024Article
- Buprenorphine discontinuation in telehealth-only treatment for opioid use disorder: A longitudinal cohort analysis.Journal of substance use and addiction treatment · 2024Observational
- Average Daily Dose Trajectories for Episodes of Buprenorphine Treatment for Opioid Use Disorder.Substance use & addiction journal · 2024Article
69 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe examined the association between the expansion of methadone and buprenorphine treatment and the prevalence of heroin overdose deaths in Baltimore, Maryland from 1995 to 2009.
methodsWe conducted a longitudinal time series analysis of archival data using linear regression with the Newey-West method to correct SEs for heteroscedasticity and autocorrelation, adjusting for average heroin purity.
resultsOverdose deaths attributed to heroin ranged from a high of 312 in 1999 to a low of 106 in 2008. While mean heroin purity rose sharply (1995-1999), the increasing number of patients treated with methadone was not associated with a change in the number of overdose deaths, but starting in 2000 expansion of opioid agonist treatment was associated with a decline in overdose deaths. Adjusting for heroin purity and the number of methadone patients, there was a statistically significant inverse relationship between heroin overdose deaths and patients treated with buprenorphine (P = .002).
conclusionsIncreased access to opioid agonist treatment was associated with a reduction in heroin overdose deaths. Implementing policies that support evidence-based medication treatment of opiate dependence may decrease heroin overdose deaths.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.