Trial reportProceedings of the National Academy of Sciences of the United States of America2013
Altered paralimbic interaction in behavioral addiction.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Brain Networks, Neurotransmitters and Psychedelics: Towards a Neurochemistry of Self-Awareness.Current neurology and neuroscience reports · 2024Review
- Computational reinforcement learning, reward (and punishment), and dopamine in psychiatric disorders.Frontiers in psychiatry · 2022Review
- Comparable level of aggression between patients with behavioural addiction and healthy subjects.Translational psychiatry · 2021Article
- A Connectomic Hypothesis for the Hominization of the Brain.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Review
- The Molecular Organization of Self-awareness: Paralimbic Dopamine-GABA Interaction.Frontiers in systems neuroscience · 2020Article
- The myeloarchitecture of impulsivity: premature responding in youth is associated with decreased myelination of ventral putamen.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Attenuation of dopamine-induced GABA release in problem gamblers.Brain and behavior · 2019Article
- Impulsivity traits and addiction-related behaviors in youth.Journal of behavioral addictions · 2018Article
- Drug Addiction: From Neuroscience to Ethics.Frontiers in psychiatry · 2018Article
- Exogenous dopamine reduces GABA receptor availability in the human brain.Brain and behavior · 2016Article
- Memory impairment and alterations in prefrontal cortex gamma band activity following methamphetamine sensitization.Psychopharmacology · 2015Article
- Making sense: Dopamine activates conscious self-monitoring through medial prefrontal cortex.Human brain mapping · 2015Article
- The developing brain in a multitasking world.Developmental review : DR · 2015Article
- Reconceptualizing anhedonia: novel perspectives on balancing the pleasure networks in the human brain.Frontiers in behavioral neuroscience · 2015Review
- Damage to insula abolishes cognitive distortions during simulated gambling.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The functional anatomy of impulse control disorders.Current neurology and neuroscience reports · 2013Review
- The concept of allosteric interaction and its consequences for the chemistry of the brain.The Journal of biological chemistry · 2013Review
- Magnetoencephalographic correlates of pornography consumption: Associations with indicators of compulsive sexual behaviors.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The introduction of magnetoencephalography has made it possible to study electromagnetic signaling in deeper, paralimbic cortical structures such as the medial prefrontal/anterior cingulate (ACC) and medial parietal/posterior cingulate (PCC) cortices. Self-awareness and self-control have been attributed to these regions. To test the hypothesis that they are dysfunctional in pathological gambling with poor self-control, we studied gamblers with and without previous stimulant abuse and age- and sex-matched controls. We found that pathological gamblers were more impulsive than controls in a stop-signal task and attributed this to changes in the activity of the paralimbic network: Pathological gamblers had reduced synchronization at rest in the high gamma range (55-100 Hz) compared with controls and failed to show an increase in gamma synchronization during rest compared with the task, as observed in controls. Subgroup analysis revealed that pathological gamblers without a history of stimulant abuse had lower PCC power during the stop-signal task compared with controls and gamblers with previous stimulant abuse. Furthermore, gamblers with a history of stimulant abuse had up to four times higher power at the ACC site during rest and the task compared with controls. In conclusion, pathological gamblers had higher impulsivity and functional paralimbic abnormalities, which could not be explained by a history of stimulant abuse. In addition, previous stimulant abuse had a marked effect on the amplitude of oscillatory brain activity in the ACC and PCC, suggesting long-term deleterious effects of repeated dopaminergic drug exposure. These consequences should be investigated in more detail in longitudinal studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.