Trial reportProceedings of the National Academy of Sciences of the United States of America2013
Assembly of complex cell microenvironments using geometrically docked hydrogel shapes.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Fabrication of Site-Specific 3D Structures via Macroscopic Supramolecular Assembly for Spatially Controlled Alignment of Multiple Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Advanced Mechanical Testing Technologies at the Cellular Level: The Mechanisms and Application in Tissue Engineering.Polymers · 2023Review
- The Effect of Geometry and TGF-β Signaling on Tumor Cell Migration from Free-Standing Microtissues.Advanced healthcare materials · 2022Article
- Thermo-sensitive Sacrificial Microsphere-based Bioink for Centimeter-scale Tissue with Angiogenesis.International journal of bioprinting · 2022Article
- Recent developments in sustainably sourced protein-based biomaterials.Biochemical Society transactions · 2021Review
- Gradient Hydrogels.Advances in biochemical engineering/biotechnology · 2021Article
- TowardsFrontiers in bioengineering and biotechnology · 2021Review
- Review
- Article
- P34HB electrospun fibres promote bone regeneration in vivo.Cell proliferation · 2019Article
- Recent Advances in Engineering the Stem Cell Microniche in 3D.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Review
- Structural analysis of photocrosslinkable methacryloyl-modified protein derivatives.Biomaterials · 2017Article
- Tunable uptake/release mechanism of protein microgel particles in biomimicking environment.Scientific reports · 2017Article
- Porous microwells for geometry-selective, large-scale microparticle arrays.Nature materials · 2017Article
- Constructing 3D heterogeneous hydrogels from electrically manipulated prepolymer droplets and crosslinked microgels.Science advances · 2016Article
- Precise Tuning of Facile One-Pot Gelatin Methacryloyl (GelMA) Synthesis.Scientific reports · 2016Article
- Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue.Advanced healthcare materials · 2016Article
- Bio-inspired 3D microenvironments: a new dimension in tissue engineering.Biomedical materials (Bristol, England) · 2016Review
- Article
- Synthesis of Cell-Adhesive Anisotropic Multifunctional Particles by Stop Flow Lithography and Streptavidin-Biotin Interactions.Langmuir : the ACS journal of surfaces and colloids · 2015Article
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Authors and funding
8 authors.
Funding
Abstract
Cellular communities in living tissues act in concert to establish intricate microenvironments, with complexity difficult to recapitulate in vitro. We report a method for docking numerous cellularized hydrogel shapes (100-1,000 µm in size) into hydrogel templates to construct 3D cellular microenvironments. Each shape can be uniquely designed to contain customizable concentrations of cells and molecular species, and can be placed into any spatial configuration, providing extensive compositional and geometric tunability of shape-coded patterns using a highly biocompatible hydrogel material. Using precisely arranged hydrogel shapes, we investigated migratory patterns of human mesenchymal stem cells and endothelial cells. We then developed a finite element gradient model predicting chemotactic directions of cell migration in micropatterned cocultures that were validated by tracking ∼2,500 individual cell trajectories. This simple yet robust hydrogel platform provides a comprehensive approach to the assembly of 3D cell environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.