ArticleProceedings of the National Academy of Sciences of the United States of America2013
Monolayer curvature stabilizes nanoscale raft domains in mixed lipid bilayers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 107 citations in OpenAlex.
- The Endoterpenoid System: A Membrane-Based Logic Framework for Integrating Cannabinoid, Olfactory, and Lipid-Sensitive Receptor Crosstalk.Journal of neuroscience research · 2026Review
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- Curvature Footprints of Transmembrane Proteins in Simulations with the Martini Force Field.The journal of physical chemistry. B · 2024Article
- Closed-loop fluid-fluid immiscibility in binary lipid-sterol membranes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Curvature-based sorting of eight lipid types in asymmetric buckled plasma membrane models.Biophysical journal · 2022Article
- Determinants of Lipid Domain Size.International journal of molecular sciences · 2022Article
- Structural and mechanical properties of the red blood cell's cytoplasmic membrane seen through the lens of biophysics.Frontiers in physiology · 2022Review
- Insights into lipid-protein interactions from computer simulations.Biophysical reviews · 2021Review
- Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders.Antioxidants (Basel, Switzerland) · 2021Review
- Pattern formation in reaction-diffusion system on membrane with mechanochemical feedback.Scientific reports · 2020Article
- All twist and no bend makes raft edges splay: Spontaneous curvature of domain edges in colloidal membranes.Science advances · 2020Article
- A Rationale for Mesoscopic Domain Formation in Biomembranes.Biomolecules · 2018Article
- Immature HIV-1 lattice assembly dynamics are regulated by scaffolding from nucleic acid and the plasma membrane.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Lipid nanodomains change ion channel function.Nanoscale · 2017Article
- Complex dynamics at the nanoscale in simple biomembranes.Scientific reports · 2017Article
- Nanoscale Membrane Domain Formation Driven by Cholesterol.Scientific reports · 2017Article
- The Molecular Structure of Human Red Blood Cell Membranes from Highly Oriented, Solid Supported Multi-Lamellar Membranes.Scientific reports · 2017Article
- The aliphatic chain of cholesterol modulates bilayer interleaflet coupling and domain registration.FEBS letters · 2016Article
- Roles of Interleaflet Coupling and Hydrophobic Mismatch in Lipid Membrane Phase-Separation Kinetics.Journal of the American Chemical Society · 2016Article
- Alteration of interleaflet coupling due to compounds displaying rapid translocation in lipid membranes.Scientific reports · 2016Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to the lipid raft hypothesis, biological lipid membranes are laterally heterogeneous and filled with nanoscale ordered "raft" domains, which are believed to play an important role for the organization of proteins in membranes. However, the mechanisms stabilizing such small rafts are not clear, and even their existence is sometimes questioned. Here, we report the observation of raft-like structures in a coarse-grained molecular model for multicomponent lipid bilayers. On small scales, our membranes demix into a liquid ordered (lo) phase and a liquid disordered (ld) phase. On large scales, phase separation is suppressed and gives way to a microemulsion-type state that contains nanometer-sized lo domains in an ld environment. Furthermore, we introduce a mechanism that generates rafts of finite size by a coupling between monolayer curvature and local composition. We show that mismatch between the spontaneous curvatures of monolayers in the lo and ld phases induces elastic interactions, which reduce the line tension between the lo and ld phases and can stabilize raft domains with a characteristic size of the order of a few nanometers. Our findings suggest that rafts in multicomponent bilayers might be closely related to the modulated ripple phase in one-component bilayers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.