ArticleProceedings of the National Academy of Sciences of the United States of America2013
Learning and reconsolidation implicate different synaptic mechanisms.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Negative allosteric modulation of mGlu7 disrupts fear memory reconsolidation and glutamatergic signaling in rat and human brain tissue.Molecular psychiatry · 2026Article
- Reactivation-induced motor skill modulation does not operate at a rapid micro-timescale level.Scientific reports · 2023Article
- Temporal prediction error triggers amygdala-dependent memory updating in appetitive operant conditioning in rats.Frontiers in behavioral neuroscience · 2022Article
- Article
- Electroconvulsive Shock Does Not Impair the Reconsolidation of Cued and Contextual Pavlovian Threat Memory.International journal of molecular sciences · 2020Article
- The dorsal hippocampus mediates synaptic destabilization and memory lability in the amygdala in the absence of contextual novelty.Neurobiology of learning and memory · 2019Article
- Mechanisms of fear learning and extinction: synaptic plasticity-fear memory connection.Psychopharmacology · 2019Review
- Acute and long-lasting effects of oxytocin in cortico-limbic circuits: consequences for fear recall and extinction.Psychopharmacology · 2019Review
- Diminishing fear: Optogenetic approach toward understanding neural circuits of fear control.Pharmacology, biochemistry, and behavior · 2018Review
- Maternal and Early Postnatal Immune Activation Produce Dissociable Effects on Neurotransmission in mPFC-Amygdala Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- New Learning and Unlearning: Strangers or Accomplices in Threat Memory Attenuation?Trends in neurosciences · 2016Review
- Activation of extracellular regulated kinase and mechanistic target of rapamycin pathway in focal cortical dysplasia.Neuropathology : official journal of the Japanese Society of Neuropathology · 2016Article
- Arc expression identifies the lateral amygdala fear memory trace.Molecular psychiatry · 2016Article
- A Model of Synaptic Reconsolidation.Frontiers in neuroscience · 2016Article
- Persistent Associative Plasticity at an Identified Synapse Underlying Classical Conditioning Becomes Labile with Short-Term Homosynaptic Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Propranolol decreases retention of fear memory by modulating the stability of surface glutamate receptor GluA1 subunits in the lateral amygdala.British journal of pharmacology · 2015Article
- Reconsolidation and the Dynamic Nature of Memory.Cold Spring Harbor perspectives in biology · 2015Review
- Deletion of Rapgef6, a candidate schizophrenia susceptibility gene, disrupts amygdala function in mice.Translational psychiatry · 2015Article
- Learning structure of sensory inputs with synaptic plasticity leads to interference.Frontiers in computational neuroscience · 2015Article
- Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition.Psychopharmacology · 2014Article
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7 authors.
Funding
Abstract
Synaptic mechanisms underlying memory reconsolidation after retrieval are largely unknown. Here we report that synapses in projections to the lateral nucleus of the amygdala implicated in auditory fear conditioning, which are potentiated by learning, enter a labile state after memory reactivation, and must be restabilized through a postsynaptic mechanism implicating the mammalian target of rapamycin kinase-dependent signaling. Fear-conditioning-induced synaptic enhancements were primarily presynaptic in origin. Reconsolidation blockade with rapamycin, inhibiting mammalian target of rapamycin kinase activity, suppressed synaptic potentiation in slices from fear-conditioned rats. Surprisingly, this reduction of synaptic efficacy was mediated by post- but not presynaptic mechanisms. These findings suggest that different plasticity rules may apply to the processes underlying the acquisition of original fear memory and postreactivational stabilization of fear-conditioning-induced synaptic enhancements mediating fear memory reconsolidation.
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