ArticleProceedings of the National Academy of Sciences of the United States of America2013
Mouse alarm pheromone shares structural similarity with predator scents.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
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Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The scent of emotions: A systematic review of human intra- and interspecific chemical communication of emotions.Brain and behavior · 2020Pooled it
- Chemical cues and molecular mechanisms suspected in abiotic stress communication.The Journal of experimental biology · 2026Article
- Environmental stress promotes the persistence of juvenile traits in olfactory neurons as a protective mechanism.iScience · 2025Article
- Hydrogen sulfide as a potent predator-derived kairomone mediating fear-related responses in mice.Communications biology · 2025Article
- Behavioral and neurobiological implications of kairomones for rodents: an updated review.Frontiers in neuroscience · 2025Review
- Development of an rpS6-Based Ex Vivo Assay for the Analysis of Neuronal Activity in Mouse and Human Olfactory Systems.International journal of molecular sciences · 2024Article
- Visual and olfactory signals of conspecifics induce emotional contagion in mice.Proceedings. Biological sciences · 2024Article
- Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice.Nature communications · 2024Article
- First Immunohistochemical Demonstration of the Expression of a Type-2 Vomeronasal Receptor, V2R2, in Wild Canids.International journal of molecular sciences · 2024Article
- CD20/MS4A1 is a mammalian olfactory receptor expressed in a subset of olfactory sensory neurons that mediates innate avoidance of predators.Nature communications · 2024Article
- CFA-treated mice induce hyperalgesia in healthy mice via an olfactory mechanism.European journal of pain (London, England) · 2024Article
- Translational models of stress and resilience: An applied neuroscience methodology review.Neuroscience applied · 2024Review
- Pheromone of grouped female mice impairs genome stability in male mice through stress-mediated pathways.Scientific reports · 2023Article
- Neural mechanisms of comforting: Prosocial touch and stress buffering.Hormones and behavior · 2023Review
- Repellent effect of synanthropic house mouse urine odor on small forest mammals.Current zoology · 2023Article
- Avoidance of thiazoline compound depends on multiple sensory pathways mediated by TrpA1 and ORs inFrontiers in molecular neuroscience · 2023Article
- Sex steroid hormone synthesis, metabolism, and the effects on the mammalian olfactory system.Cell and tissue research · 2023Review
- Chronic Unpredictable Mild Stress Model of Depression: Possible Sources of Poor Reproducibility and Latent Variables.Biology · 2022Review
- Multimodal Cues Do Not Improve Predator Recognition in Green Toad Tadpoles.Animals : an open access journal from MDPI · 2022Article
- Fear effects on bank voles (Rodentia: Arvicolinae): testing for repellent candidates from predator volatiles.Pest management science · 2022Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensing the chemical warnings present in the environment is essential for species survival. In mammals, this form of danger communication occurs via the release of natural predator scents that can involuntarily warn the prey or by the production of alarm pheromones by the stressed prey alerting its conspecifics. Although we previously identified the olfactory Grueneberg ganglion as the sensory organ through which mammalian alarm pheromones signal a threatening situation, the chemical nature of these cues remains elusive. We here identify, through chemical analysis in combination with a series of physiological and behavioral tests, the chemical structure of a mouse alarm pheromone. To successfully recognize the volatile cues that signal danger, we based our selection on their activation of the mouse olfactory Grueneberg ganglion and the concomitant display of innate fear reactions. Interestingly, we found that the chemical structure of the identified mouse alarm pheromone has similar features as the sulfur-containing volatiles that are released by predating carnivores. Our findings thus not only reveal a chemical Leitmotiv that underlies signaling of fear, but also point to a double role for the olfactory Grueneberg ganglion in intraspecies as well as interspecies communication of danger.
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