ArticleFrontiers in plant science2013
Hexose kinases and their role in sugar-sensing and plant development.
Article in Frontiers in plant science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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105 citing papers in PubMed, 257 citations in OpenAlex.
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- Decoding the sugar-strigolactone crosstalk: new frontier in plant growth and stress resilience.Horticulture research · 2026Article
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- Identification of Candidate Gene Networks Controlling Soluble Sugar Metabolism DuringFoods (Basel, Switzerland) · 2025Article
- Identification and expression analysis of the FRK gene family in Oilseed (Brassica napus L.).BMC plant biology · 2025Article
- Ethylene-releasing plant growth regulators promote ripening initiation by stimulating sugar, acid and anthocyanin metabolism in blueberry (Vaccinium ashei).BMC plant biology · 2025Article
- Grain under pressure: Harnessing biochemical pathways to beat drought and heat in wheat.The Plant journal : for cell and molecular biology · 2025Review
- Regulatory role of exogenous 24-epibrassinolide on tomato fruit quality.BMC plant biology · 2025Article
- Genomic Analysis of Hexokinase Genes in Foxtail Millet (International journal of molecular sciences · 2025Article
- Identification and functional characterization of a fructose-inducible phosphotransferase system inApplied and environmental microbiology · 2025Article
- Genome-Wide Identification and Expression Analysis of Hexokinase Gene Family Under Abiotic Stress in Tomato.Plants (Basel, Switzerland) · 2025Article
- Interplay Between Phytohormones and Sugar Metabolism inPlants (Basel, Switzerland) · 2025Review
- Identification ofInternational journal of molecular sciences · 2025Article
- Transcriptome and selected metabolite analyses reveal points of sugar metabolism in the developing leaves of kiwifruit.Frontiers in plant science · 2025Article
- Metabolomic and transcriptomic insights into the mechanism of sugar and acid accumulation in the pulp of sour- and sweet-tastingFrontiers in plant science · 2025Article
45 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hexose sugars, such as glucose and fructose produced in plants, are ubiquitous in most organisms and are the origin of most of the organic matter found in nature. To be utilized, hexose sugars must first be phosphorylated. The central role of hexose-phosphorylating enzymes has attracted the attention of many researchers, leading to novel discoveries. Only two families of enzymes capable of phosphorylating glucose and fructose have been identified in plants; hexokinases (HXKs), and fructokinases (FRKs). Intensive investigations of these two families in numerous plant species have yielded a wealth of knowledge regarding the genes number, enzymatic characterization, intracellular localization, and developmental and physiological roles of several HXKs and FRKs. The emerging picture indicates that HXK and FRK enzymes found at specific intracellular locations play distinct roles in plant metabolism and development. Individual HXKs were shown for the first time to be dual-function enzymes - sensing sugar levels independent of their catalytic activity and controlling gene expression and major developmental pathways, as well as hormonal interactions. FRK, on the other hand, seems to play a central metabolic role in vascular tissues, controlling the amounts of sugars allocated for vascular development. While a clearer picture of the roles of these two types of enzymes is emerging, many questions remain unsolved, such as the specific tissues and types of cells in which these enzymes function, the roles of individual HXK and FRK genes, and how these enzymes interact with hormones in the regulation of developmental processes. It is anticipated that ongoing efforts will broaden our knowledge of these important plant enzymes and their potential uses in the modification of plant traits.
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