ArticleJournal of virology2013
Pathogenesis, transmissibility, and ocular tropism of a highly pathogenic avian influenza A (H7N3) virus associated with human conjunctivitis.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 65 citations in OpenAlex.
- Route of Inoculation Determines Symptom Profile and Replication Dynamics After low Pathogenic Avian Influenza A(H7N9) Virus Infection in Ferrets.Influenza and other respiratory viruses · 2025Article
- Update on Ophthalmic Implications of Highly Pathogenic Avian Influenza A (H5N1) Virus.Pathogens (Basel, Switzerland) · 2025Review
- Influenza-Associated Ocular Complications: A Comprehensive Review of Viral Subtypes, Clinical Presentations, and Vaccination Risks.Vaccines · 2025Review
- [Brief history of laboratory-based epidemiological surveillance in the Mexican Institute for Social Security].Revista medica del Instituto Mexicano del Seguro Social · 2025Article
- New-onset conjunctivitis 3.5 years post SARS-CoV-2 infection in an inner-city population in the Bronx.BMJ open ophthalmology · 2025Article
- [Epidemiological surveillance at IMSS: a review of institutional successes].Revista medica del Instituto Mexicano del Seguro Social · 2025Article
- [Avian influenza: a latent challenge].Revista medica del Instituto Mexicano del Seguro Social · 2024Article
- Quantitative measurement of influenza virus transmission in animal model: an overview of current state.Biophysical reviews · 2023Review
- Utility of HumanJournal of virology · 2023Article
- Evolution of the North American Lineage H7 Avian Influenza Viruses in Association with H7 Virus's Introduction to Poultry.Journal of virology · 2022Article
- Inherent Heterogeneity of Influenza A Virus Stability following Aerosolization.Applied and environmental microbiology · 2022Article
- The eye as the discrete but defensible portal of coronavirus infection.The ocular surface · 2021Review
- Mammalian pathogenicity and transmissibility of low pathogenic avian influenza H7N1 and H7N3 viruses isolated from North America in 2018.Emerging microbes & infections · 2020Article
- Insights into species-specific regulation of ANP32A on the mammalian-restricted influenza virus polymerase activity.Emerging microbes & infections · 2019Article
- Mammalian Pathogenesis and Transmission of Avian Influenza A(H7N9) Viruses, Tennessee, USA, 2017.Emerging infectious diseases · 2018Article
- Inactivated H7 Influenza Virus Vaccines Protect Mice despite Inducing Only Low Levels of Neutralizing Antibodies.Journal of virology · 2017Article
- Pathogenesis, Transmissibility, and Tropism of a Highly Pathogenic Avian Influenza A(H7N7) Virus Associated With Human Conjunctivitis in Italy, 2013.The Journal of infectious diseases · 2017Article
- Immunocapture isotope dilution mass spectrometry in response to a pandemic influenza threat.Vaccine · 2017Article
- The PB2 mutation with lysine at 627 enhances the pathogenicity of avian influenza (H7N9) virus which belongs to a non-zoonotic lineage.Scientific reports · 2017Article
- Potential for Low-Pathogenic Avian H7 Influenza A Viruses To Replicate and Cause Disease in a Mammalian Model.Journal of virology · 2017Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
H7 subtype influenza A viruses, responsible for numerous outbreaks in land-based poultry in Europe and the Americas, have caused over 100 cases of confirmed or presumed human infection over the last decade. The emergence of a highly pathogenic avian influenza H7N3 virus in poultry throughout the state of Jalisco, Mexico, resulting in two cases of human infection, prompted us to examine the virulence of this virus (A/Mexico/InDRE7218/2012 [MX/7218]) and related avian H7 subtype viruses in mouse and ferret models. Several high- and low-pathogenicity H7N3 and H7N9 viruses replicated efficiently in the respiratory tract of mice without prior adaptation following intranasal inoculation, but only MX/7218 virus caused lethal disease in this species. H7N3 and H7N9 viruses were also detected in the mouse eye following ocular inoculation. Virus from both H7N3 and H7N9 subtypes replicated efficiently in the upper and lower respiratory tracts of ferrets; however, only MX/7218 virus infection caused clinical signs and symptoms and was capable of transmission to naive ferrets in a direct-contact model. Similar to other highly pathogenic H7 viruses, MX/7218 replicated to high titers in human bronchial epithelial cells, yet it downregulated numerous genes related to NF-κB-mediated signaling transduction. These findings indicate that the recently isolated North American lineage H7 subtype virus associated with human conjunctivitis is capable of causing severe disease in mice and spreading to naive-contact ferrets, while concurrently retaining the ability to replicate within ocular tissue and allowing the eye to serve as a portal of entry.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.