ArticlePlant physiology2013
Transcriptomic analysis of the role of carboxylic acids in metabolite signaling in Arabidopsis leaves.
Article in Plant physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 95 citations in OpenAlex.
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- Linking mitochondrial and chloroplast retrograde signalling in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Two tightly linked genes coding for NAD-dependent malic enzyme and dynamin-related protein are associated with resistance to Cercospora leaf spot disease in cowpea (Vigna unguiculata (L.) Walp.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Improved water use efficiency and shorter life cycle of Nicotiana tabacum due to modification of guard and vascular companion cells.Scientific reports · 2018Article
- Mitochondrial Energy Signaling and Its Role in the Low-Oxygen Stress Response of Plants.Plant physiology · 2018Review
- Altered Expression of the Malate-Permeable Anion Channel OsALMT4 Reduces the Growth of Rice Under Low Radiance.Frontiers in plant science · 2018Article
- Tricarboxylates Induce Defense Priming Against Bacteria inFrontiers in plant science · 2018Article
- NADP-Dependent Malic Enzyme 1 Participates in the Abscisic Acid Response inFrontiers in plant science · 2018Article
- Modifications in Organic Acid Profiles During Fruit Development and Ripening: Correlation or Causation?Frontiers in plant science · 2018Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcriptional response to metabolites is an important mechanism by which plants integrate information about cellular energy and nutrient status. Although some carboxylic acids have been implicated in the regulation of gene expression for select transcripts, it is unclear whether all carboxylic acids have the same effect, how many transcripts are affected, and how carboxylic acid signaling is integrated with other metabolite signals. In this study, we demonstrate that perturbations in cellular concentrations of citrate, and to a lesser extent malate, have a major impact on nucleus-encoded transcript abundance. Functional categories of transcripts that were targeted by both organic acids included photosynthesis, cell wall, biotic stress, and protein synthesis. Specific functional categories that were only regulated by citrate included tricarboxylic acid cycle, nitrogen metabolism, sulfur metabolism, and DNA synthesis. Further quantitative real-time polymerase chain reaction analysis of specific citrate-responsive transcripts demonstrated that the transcript response to citrate is time and concentration dependent and distinct from other organic acids and sugars. Feeding of isocitrate as well as the nonmetabolizable citrate analog tricarballylate revealed that the abundance of selected marker transcripts is responsive to citrate and not downstream metabolites. Interestingly, the transcriptome response to citrate feeding was most similar to those observed after biotic stress treatments and the gibberellin biosynthesis inhibitor paclobutrazol. Feeding of citrate to mutants with defects in plant hormone signaling pathways did not completely abolish the transcript response but hinted at a link with jasmonic acid and gibberellin signaling pathways. Our results suggest that changes in carboxylic acid abundances can be perceived and signaled in Arabidopsis (Arabidopsis thaliana) by as yet unknown signaling pathways.
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