ArticleDevelopment (Cambridge, England)2013
Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 73 citations in OpenAlex.
- Organoid-loaded core-shell cryomicroneedles induce biomimetic follicular units and hair regeneration.Bioactive materials · 2026Article
- Single cell multi-omics enables high-resolution identification and functional purification of human acute myeloid leukemia stem cells.bioRxiv : the preprint server for biology · 2026Article
- Molecular signatures and signaling interactions of the hair follicle stem cell niche.The Journal of investigative dermatology · 2026Article
- Triggering AHR resolves TGF-β1 induced fibroblast activation and promotes AT1 cell regeneration in alveolar organoids.Communications biology · 2025Article
- Molecular cascade reveals sequential milestones underlying hippocampal neural stem cell development into an adult state.Cell reports · 2024Article
- CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system.Bioinformatics (Oxford, England) · 2023Article
- Review
- Article
- Stem cell-intrinsic mechanisms regulating adult hair follicle homeostasis.Experimental dermatology · 2021Review
- Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory disease.eLife · 2021Article
- NFAT5 Controls the Integrity of Epidermis.Frontiers in immunology · 2021Article
- A Two-Step Process of Effector Programming Governs CD4Cell reports · 2020Article
- STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury.Nature cell biology · 2020Article
- HOPX regulates bone marrow-derived mesenchymal stromal cell fate determination via suppression of adipogenic gene pathways.Scientific reports · 2020Article
- Knock-out of Hopx disrupts stemness and quiescence of hematopoietic stem cells in mice.Oncogene · 2020Article
- Time after time: circadian clock regulation of intestinal stem cells.Cellular and molecular life sciences : CMLS · 2020Review
- The role of HOPX in normal tissues and tumor progression.Bioscience reports · 2020Review
- Article
- Developmental plasticity of epithelial stem cells in tooth and taste bud renewal.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian hair follicle relies on adult resident stem cells and their progeny to fuel and maintain hair growth throughout the life of an organism. The cyclical and initially synchronous nature of hair growth makes the hair follicle an ideal system with which to define homeostatic mechanisms of an adult stem cell population. Recently, we demonstrated that Hopx is a specific marker of intestinal stem cells. Here, we show that Hopx specifically labels long-lived hair follicle stem cells residing in the telogen basal bulge. Hopx(+) cells contribute to all lineages of the mature hair follicle and to the interfollicular epidermis upon epidermal wounding. Unexpectedly, our analysis identifies a previously unappreciated progenitor population that resides in the lower hair bulb of anagen-phase follicles and expresses Hopx. These cells co-express Lgr5, do not express Shh and escape catagen-induced apoptosis. They ultimately differentiate into the cytokeratin 6-positive (K6) inner bulge cells in telogen, which regulate the quiescence of adjacent hair follicle stem cells. Although previous studies have suggested that K6(+) cells arise from Lgr5-expressing lower outer root sheath cells in anagen, our studies indicate an alternative origin, and a novel role for Hopx-expressing lower hair bulb progenitor cells in contributing to stem cell homeostasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.