ArticleJournal of cell science2013
Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels.
Article in Journal of cell science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 21 citations in OpenAlex.
- Proper localization of the SCA13-linked KNeurobiology of disease · 2026Article
- AProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Blocking axon-glial mechanotransduction to prevent concussive brain injury.Acta neuropathologica communications · 2025Article
- The Mechanical Microenvironment Regulates Axon Diameters Visualized by Cryo-Electron Tomography.Cells · 2022Article
- Biophysical KeLife · 2022Article
- Immediate induction of varicosities by transverse compression but not uniaxial stretch in axon mechanosensation.Acta neuropathologica communications · 2022Article
- Advances in the study of axon-associated vesicles.Frontiers in molecular neuroscience · 2022Review
- Molecular mechanism for kinesin-1 direct membrane recognition.Science advances · 2021Article
- Region-specific interneuron demyelination and heightened anxiety-like behavior induced by adolescent binge alcohol treatment.Acta neuropathologica communications · 2019Article
- Distinct Distribution Patterns of Potassium Channel Sub-Units in Somato-Dendritic Compartments of Neurons of the Medial Superior Olive.Frontiers in cellular neuroscience · 2019Article
- Balanced Activity between Kv3 and Nav Channels Determines Fast-Spiking in Mammalian Central Neurons.iScience · 2018Article
- Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal Endurance.Physiological reviews · 2017Review
- Polarity of varicosity initiation in central neuron mechanosensation.The Journal of cell biology · 2017Article
- SKIP controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain.Journal of cell science · 2017Article
- Suppression of Inflammatory Demyelinaton and Axon Degeneration through Inhibiting Kv3 Channels.Frontiers in molecular neuroscience · 2017Article
- Regulation of neurovascular coupling in autoimmunity to water and ion channels.Autoimmunity reviews · 2015Review
- Physiological and pathological functions of mechanosensitive ion channels.Molecular neurobiology · 2014Review
- Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons.Developmental cell · 2014Article
- Astrocytes differentially respond to inflammatory autoimmune insults and imbalances of neural activity.Acta neuropathologica communications · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The conventional kinesin motor transports many different cargos to specific locations in neurons. How cargos regulate motor function remains unclear. Here we focus on KIF5, the heavy chain of conventional kinesin, and report that the Kv3 (Shaw) voltage-gated K(+) channel, the only known tetrameric KIF5-binding protein, clusters and activates KIF5 motors during axonal transport. Endogenous KIF5 often forms clusters along axons, suggesting a potential role of KIF5-binding proteins. Our biochemical assays reveal that the high-affinity multimeric binding between the Kv3.1 T1 domain and KIF5B requires three basic residues in the KIF5B tail. Kv3.1 T1 competes with the motor domain and microtubules, but not with kinesin light chain 1 (KLC1), for binding to the KIF5B tail. Live-cell imaging assays show that four KIF5-binding proteins, Kv3.1, KLC1 and two synaptic proteins SNAP25 and VAMP2, differ in how they regulate KIF5B distribution. Only Kv3.1 markedly increases the frequency and number of KIF5B-YFP anterograde puncta. Deletion of Kv3.1 channels reduces KIF5 clusters in mouse cerebellar neurons. Therefore, clustering and activation of KIF5 motors by Kv3 regulate the motor number in carrier vesicles containing the channel proteins, contributing not only to the specificity of Kv3 channel transport, but also to the cargo-mediated regulation of motor function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.