ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
The balance of striatal feedback transmission is disrupted in a model of parkinsonism.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Pathological cell assembly dynamics in a striatal MSN network model.Frontiers in computational neuroscience · 2024Article
- The impact of Parkinson's disease on striatal network connectivity and corticostriatal drive: An in silico study.Network neuroscience (Cambridge, Mass.) · 2024Article
- Ongoing movement controls sensory integration in the dorsolateral striatum.Nature communications · 2023Article
- Basal ganglia for beginners: the basic concepts you need to know and their role in movement control.Frontiers in systems neuroscience · 2023Review
- Reversal of pathological motor behavior in a model of Parkinson's disease by striatal dopamine uncaging.PloS one · 2023Article
- Exercise improves behavioral dysfunction and inhibits the spontaneous excitatory postsynaptic current of D2-medium spiny neurons.Frontiers in aging neuroscience · 2022Article
- Segregation of D1 and D2 dopamine receptors in the striatal direct and indirect pathways: An historical perspective.Frontiers in synaptic neuroscience · 2022Review
- Striatal network modeling in Huntington's Disease.PLoS computational biology · 2020Article
- Synchronized activation of striatal direct and indirect pathways underlies the behavior in unilateral dopamine-depleted mice.The European journal of neuroscience · 2019Article
- Exploring the role of striatal D1 and D2 medium spiny neurons in action selection using a virtual robotic framework.The European journal of neuroscience · 2019Article
- Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales-Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.2.Frontiers in neural circuits · 2018Review
- Dopaminergic treatment weakens medium spiny neuron collateral inhibition in the parkinsonian striatum.Journal of neurophysiology · 2017Article
- Homologous Basal Ganglia Network Models in Physiological and Parkinsonian Conditions.Frontiers in computational neuroscience · 2017Article
- A Low-Correlation Resting State of the Striatum during Cortical Avalanches and Its Role in Movement Suppression.PLoS biology · 2016Article
- Loss of Homeostasis in the Direct Pathway in a Mouse Model of Asymptomatic Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Cell Assembly Dynamics of Sparsely-Connected Inhibitory Networks: A Simple Model for the Collective Activity of Striatal Projection Neurons.PLoS computational biology · 2016Article
- Pallidal Deep Brain Stimulation Improves Higher Control of the Oculomotor System in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Desynchronization of fast-spiking interneurons reduces β-band oscillations and imbalance in firing in the dopamine-depleted striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Diverse Short-Term Dynamics of Inhibitory Synapses Converging on Striatal Projection Neurons: Differential Changes in a Rodent Model of Parkinson's Disease.Neural plasticity · 2015Article
- Parkinsonism and inborn errors of metabolism.Journal of inherited metabolic disease · 2014Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inhibitory connections among striatal projection neurons (SPNs) called "feedback inhibition," have been proposed to endow the striatal microcircuit with computational capabilities, such as motor sequence selection, filtering, and the emergence of alternating network states. These properties are disrupted in models of Parkinsonism. However, the impact of feedback inhibition in the striatal network has remained under debate. Here, we test this inhibition at the microcircuit level. We used optical and electrophysiological recordings in mice and rats to demonstrate the action of striatal feedback transmission in normal and pathological conditions. Dynamic calcium imaging with single-cell resolution revealed the synchronous activation of a pool of identified SPNs by antidromic stimulation. Using bacterial artificial chromosome-transgenic mice, we demonstrate that the activated neuron pool equally possessed cells from the direct and indirect basal ganglia pathways. This pool inhibits itself because of its own GABA release when stimuli are frequent enough, demonstrating functional and significant inhibition. Blockade of GABAA receptors doubled the number of responsive neurons to the same stimulus, revealing a second postsynaptic neuron pool whose firing was being arrested by the first pool. Stronger connections arise from indirect SPNs. Dopamine deprivation impaired striatal feedback transmission disrupting the ability of a neuronal pool to arrest the firing of another neuronal pool. We demonstrate that feedback inhibition among SPNs is strong enough to control the firing of cell ensembles in the striatal microcircuit. However, to be effective, feedback inhibition should arise from synchronized pools of SPNs whose targets are other SPNs pools.
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