ArticleStem cells translational medicine2013
Integration and regression of implanted engineered human vascular networks during deep wound healing.
Article in Stem cells translational medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
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- Bottom-up Biomaterial strategies for creating tailored stem cells in regenerative medicine.Frontiers in bioengineering and biotechnology · 2025Review
- Multi-parameter tunable synthetic matrix for engineering lymphatic vessels.Communications biology · 2024Article
- Signaling Pathways Triggering Therapeutic Hydrogels in Promoting Chronic Wound Healing.Macromolecular bioscience · 2024Review
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- Enhancing human capillary tube network assembly and maturation through upregulated expression of pericyte-derived TIMP-3.Frontiers in cell and developmental biology · 2024Article
- Engineering bioactive nanoparticles to rejuvenate vascular progenitor cells.Communications biology · 2022Article
- Recent Advances in Bioengineered Scaffolds for Cutaneous Wound Healing.Frontiers in bioengineering and biotechnology · 2022Review
- Biomimetic Hydrogels to Promote Wound Healing.Frontiers in bioengineering and biotechnology · 2021Review
- An Integrated Smart Sensor Dressing for Real-Time Wound Microenvironment Monitoring and Promoting Angiogenesis and Wound Healing.Frontiers in cell and developmental biology · 2021Article
- Effect of Hypoxia Preconditioned Secretomes on Lymphangiogenic and Angiogenic Sprouting: An in Vitro Analysis.Biomedicines · 2020Article
- Accelerate Healing of Severe Burn Wounds by Mouse Bone Marrow Mesenchymal Stem Cell-Seeded Biodegradable Hydrogel Scaffold Synthesized from Arginine-Based Poly(ester amide) and Chitosan.Stem cells and development · 2018Article
- Lymphatic Tissue Engineering and Regeneration.Journal of biological engineering · 2018Review
- Advances in keratinocyte delivery in burn wound care.Advanced drug delivery reviews · 2018Review
- A novel method for fabricating engineered structures with branched micro-channel using hollow hydrogel fibers.Biomicrofluidics · 2016Article
- Diabetic wound regeneration using peptide-modified hydrogels to target re-epithelialization.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Acellular Hydrogels for Regenerative Burn Wound Healing: Translation from a Porcine Model.The Journal of investigative dermatology · 2015Article
- Endothelial Network Formation Within Human Tissue-Engineered Skeletal Muscle.Tissue engineering. Part A · 2015Article
- HYDROGEL-BASED NANOCOMPOSITES OF THERAPEUTIC PROTEINS FOR TISSUE REPAIR.Current opinion in chemical engineering · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The ability of vascularized constructs to integrate with tissues may depend on the kinetics and stability of vascular structure development. This study assessed the functionality and durability of engineered human vasculatures from endothelial progenitors when implanted in a mouse deep burn-wound model. Human vascular networks, derived from endothelial colony-forming cells in hyaluronic acid hydrogels, were transplanted into third-degree burns. On day 3 following transplantation, macrophages rapidly degraded the hydrogel during a period of inflammation; through the transitions from inflammation to proliferation (days 5-7), the host's vasculatures infiltrated the construct, connecting with the human vessels within the wound area. The growth of mouse vessels near the wound area supported further integration with the implanted human vasculatures. During this period, the majority of the vessels (∼60%) in the treated wound area were human. Although no increase in the density of human vessels was detected during the proliferative phase, they temporarily increased in size. This growth peaked at day 7, the middle of the proliferation stage, and then decreased by the end of the proliferation stage. As the wound reached the remodeling period during the second week after transplantation, the vasculatures including the transplanted human vessels generally regressed, and few microvessels, wrapped by mouse smooth muscle cells and with a vessel area less than 200 μm² (including the human ones), remained in the healed wound. Overall, this study offers useful insights for the development of vascularization strategies for wound healing and ischemic conditions, for tissue-engineered constructs, and for tissue regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.