Trial reportNeuro-oncology2013
Trends in treatment and outcomes of pediatric craniopharyngioma, 1975-2011.
Trial report in Neuro-oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Visual functions in children with craniopharyngioma at diagnosis: A systematic review.PloS one · 2020Pooled it
- Phase II study of peginterferon alpha-2b for patients with unresectable or recurrent craniopharyngiomas: a Pediatric Brain Tumor Consortium report.Neuro-oncology · 2020Trial
- Nuchal Skinfold Thickness: A Novel Parameter for Assessment of Body Composition in Childhood Craniopharyngioma.The Journal of clinical endocrinology and metabolism · 2016Trial
- Efficacy and safety of BRAF-MEK inhibitors in treatment of Chinese patients with papillary craniopharyngioma: A retrospective cohort study.Molecular therapy. Oncology · 2025Article
- Case-based review: Craniopharyngioma treated with intracystic peginterferon.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Article
- Long-term outcome of childhood and adolescent patients with craniopharyngiomas: a single center retrospective experience.BMC cancer · 2024Article
- Multiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization.Cell death & disease · 2024Article
- An update on multimodal management of craniopharyngioma in children.Frontiers in oncology · 2023Article
- Spinal ectopic recurrence of craniopharyngioma in a pediatric patient.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Socio-behavioral dysfunction in disorders of hypothalamic-pituitary involvement: The potential role of disease-induced oxytocin and vasopressin signaling deficits.Neuroscience and biobehavioral reviews · 2022Review
- CBX4-dependent regulation of HDAC3 nuclear translocation reduces Bmp2-induced osteoblastic differentiation and calcification in adamantinomatous craniopharyngioma.Cell communication and signaling : CCS · 2022Article
- Biochemical profile of paediatric adamantinomatous craniopharyngiomas: A prospective cohort study.Frontiers in surgery · 2022Article
- Immune infiltration in aggressive papillary craniopharyngioma: High infiltration but low action.Frontiers in immunology · 2022Article
- The function of adrenal glands in children and adolescents during and after oncological treatment.Pediatric endocrinology, diabetes, and metabolism · 2022Review
- Stereotactic cysto-ventricular catheters in craniopharyngiomas: an effective minimally invasive method to improve visual impairment and achieve long-term cyst volume reduction.Neurosurgical review · 2021Article
- Characteristics and overall survival in pediatric versus adult craniopharyngioma: a population-based study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Endoscopic extended transsphenoidal surgery for newly diagnosed paediatric craniopharyngiomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- The STAR/HOP system: a newly proposed abbreviated descriptive clinical coding system for craniopharyngiomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Postoperative MR imaging surveillance of pediatric craniopharyngioma: new institutional guidelines.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCraniopharyngioma tumors and their treatment can lead to significant long-term morbidity due to their proximity to vital structures. The optimal treatment has been debated for many years. We aimed to review the long-term outcomes of children treated for craniopharyngioma in our institution over the past decade and describe trends in treatment and outcomes over the past 3 decades.
methodsCharts of children with craniopharyngioma treated and followed at The Hospital for Sick Children between 2001 and 2011 were reviewed. Data regarding findings at diagnosis, treatment, and long-term outcomes were analyzed. Comparison was made with previously published data from our institution.
resultsData from 33 patients are included; mean age at treatment, 10.7 ± 4.8 years. In 18 children (55%), the initial surgical approach was tumor cyst decompression with or without adjuvant therapy, compared with only 0-2% in the preceding decades (P < .01). Diabetes insipidus occurred in 55% of children and panhypopituitarism in 58% compared with 88% (P < .01) and 86% (P < .01), respectively, in the previous 10 years. Overall, there was a 36% reduction in the number of children who developed severe obesity compared with the preceding decade. Body mass index at follow-up was associated with body mass index at diagnosis (P = .004) and tumor resection as an initial treatment approach (P = .028).
conclusionsA shift in surgical treatment approach away from gross total resection has led to improved endocrine outcomes. This may have beneficial implications for quality of life in survivors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.