ArticleEuropean journal of human genetics : EJHG2013
Genetics of eye colours in different rural populations on the Silk Road.
Article in European journal of human genetics : EJHG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Predictive accuracy of genetic variants for eye color in a Kazakh population using the IrisPlex system.BMC research notes · 2024Article
- Impact of cultural and genetic structure on food choices along the Silk Road.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Eye color prediction using single nucleotide polymorphisms in Saudi population.Saudi journal of biological sciences · 2019Article
- HERCing: Structural and Functional Relevance of the Large HERC Ubiquitin Ligases.Frontiers in physiology · 2019Review
- Genetic landscape of populations along the Silk Road: admixture and migration patterns.BMC genetics · 2014Article
- IRIS COLOUR CLASSIFICATION SCALES--THEN AND NOW.Romanian journal of ophthalmologyReview
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eye colour is a highly transmissible and discernible trait in humans. A genome-wide association scan for variants associated to eye pigmentation was carried out on a large group of individuals coming from the Silk Road. Significant associations were detected not only with HERC2 (P-value=4.99 × 10(-37)) and OCA2 (P-value=4.51 × 10(-9)) genes but also with CTNNA2 gene (P-value=4.06 × 10(-8)). Moreover, the multifactor dimensionality reduction analysis clearly showed the effect of HERC2 haplotype over OCA2 mostly associated with SNP, thus enabling a highly accurate eye-colour prediction. Finally, the regression tree analysis showed that individuals carrying a given combination of haplotypes have a significant probability to show a blue or green/grey iris colour as compared with brown, with a gradient from west to east.
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Registered trials
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