ArticleAutophagy2013
Tumor suppressor gene PDCD4 negatively regulates autophagy by inhibiting the expression of autophagy-related gene ATG5.
Article in Autophagy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Pooled it
- PDCD4: A Double-Edged Sword in Neurological Diseases.Molecular neurobiology · 2026Review
- Traditional Chinese medicine in lung cancer treatment.Molecular cancer · 2025Review
- PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Programmed cell death 4 blocks autophagy and promotes dopaminergic neuronal injury in Parkinson's disease.Experimental and therapeutic medicine · 2024Article
- Cold exposure protects against medial arterial calcification development via autophagy.Journal of nanobiotechnology · 2023Article
- Downregulation of miRNA-21 and cancer stem cells after chemotherapy results in better outcome in breast cancer patients.World journal of stem cells · 2022Article
- Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation.Cell death and differentiation · 2021Article
- Recent developments in autophagy-targeted therapies in cancer.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Forkhead box P3 promotes breast cancer cell apoptosis by regulating programmed cell death 4 expression.Oncology letters · 2020Article
- PDCD4 deficiency ameliorates left ventricular remodeling and insulin resistance in a rat model of type 2 diabetic cardiomyopathy.BMJ open diabetes research & care · 2020Article
- Phytochemicals for the Prevention and Treatment of Gastric Cancer: Effects and Mechanisms.International journal of molecular sciences · 2020Review
- The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation.Science advances · 2019Article
- Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-1-regulated apoptosis in pancreatic cancer cells.Cancer biology & therapy · 2019Article
- Role of programmed cell death 4 in diseases: a double-edged sword.Cellular & molecular immunology · 2017Article
- Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells.Oncotarget · 2017Article
- Programmed cell death 4 and BCR-ABL fusion gene expression are negatively correlated in chronic myeloid leukemia.Oncology letters · 2016Article
- Pdcd4 deficiency enhances macrophage lipoautophagy and attenuates foam cell formation and atherosclerosis in mice.Cell death & disease · 2016Article
- Cullin-RING ligases in regulation of autophagy.Cell division · 2016Review
- Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia.Oncotarget · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PDCD4 (programmed cell death protein 4), a suppressor of gene transcription and translation, plays a crucial inhibitory role in several types of human tumors. However, its underlying mechanisms remain unclear. Autophagy, an evolutionarily conserved catabolic process, maintains cellular homeostasis under stress conditions such as starvation and plays a crucial role in tumor initiation and progression. We report here that PDCD4 inhibits autophagy in multiple cell types both in vitro and in vivo, which in turn contributes to its tumor suppressor activity. Importantly, PDCD4 inhibits the expression of an essential autophagy related gene, ATG5 and the formation of an ATG12-ATG5 complex, and its ma3 domains are required for PDCD4-mediated inhibition of autophagy. Unlike most tumor suppressors that act as positive or dual regulators of autophagy, our findings indicate that PDCD4 negatively regulates autophagy by targeting ATG5, which provides a novel mechanism of tumor suppression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.