Trial reportNutrients2013
Pathology of bursae of Fabricius in methionine-deficient broiler chickens.
Trial report in Nutrients, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Dietary supplementation with stabilized products of sorghum enriched with lactobacilli improves growth performance and antioxidant defense and modulates hematological parameters in indigenous guinea keets.Tropical animal health and production · 2026Article
- Alleviating heat stress-induced immune organ damage in ducks: Role of melittin.Tropical animal health and production · 2025Article
- Early embryonic thermal programming and post-hatch flavonoid (Frontiers in veterinary science · 2025Article
- Effects of methionine supplementation in a reduced protein diet on growth performance, oxidative status, intestinal health, oocyst shedding, and methionine and folate metabolism in broilers under Eimeria challenge.Journal of animal science and biotechnology · 2024Article
- The Functional Roles of Methionine and Arginine in Intestinal and Bone Health of Poultry: Review.Animals : an open access journal from MDPI · 2023Review
- Dietary Methionine Increased the Growth Performances and Immune Function of Partridge Shank Broilers after Challenged with Coccidia.Animals : an open access journal from MDPI · 2023Article
- Methionine Deficiency Affects Liver and Kidney Health, Oxidative Stress, and Ileum Mucosal Immunity in Broilers.Frontiers in veterinary science · 2021Article
- Effects of different levels of arginine and methionine in a high-lysine diet on the immune status, performance, and carcass traits of turkeys.Poultry science · 2020Article
- The Effect ofAnimals : an open access journal from MDPI · 2020Article
- Dietary methionine level alters growth, digestibility, and gene expression of amino acid transporters in meat-type chickens.Poultry science · 2020Article
- Effects of dietary methionine plus cysteine levels on growth performance and intestinal antibody production in broilers during Eimeria challenge.Poultry science · 2020Article
- Heat Stress Causes Immune Abnormalities via Massive Damage to Effect Proliferation and Differentiation of Lymphocytes in Broiler Chickens.Frontiers in veterinary science · 2020Article
- Effect of methionine deficiency on duodenal and jejunal IgAIranian journal of veterinary research · 2018Article
- Toxic effect of NiCl2 on development of the bursa of Fabricius in broiler chickens.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this 42-day study was to investigate the effects of methionine (Met) deficiency on immune function by determining the relative weight, morphological and ultrastructural changes of bursae of Fabricius, cell cycle, and apoptosis of bursa cells. One hundred and twenty one-day-old avian broilers were randomly divided into two groups and fed on a control diet (starter diet, Met 0.50%; grower diet, Met 0.40%) and Met-deficient diet (starter diet, Met 0.26%; grower diet, Met 0.28%) for six weeks. The relative weight of bursae was decreased with Met deficiency when compared to that of the control group. Lesions were also observed in the Met-deficient group. Histopathologically, the numbers of lymphocytes in the follicles were decreased. Ultrastructurally, the mitochondria of lymphocytes were swollen in the Met-deficient group. As measured by flow cytometry, bursal cells in the G0G1 phase were significantly higher (P < 0.01), and bursal cells in the S, G2M phases and proliferating index were obviously lower (P < 0.01) with Met deficiency than in the control group. Moreover, the percentage of apoptotic cells in the bursae were significantly increased in Met-deficient birds (P < 0.01). It was concluded that Met deficiency restrained the development of the bursae of Fabricius and affected the humoral immunity of the chickens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.