ArticleJournal of the Royal Society, Interface2013
Morpho-elasticity of intestinal villi.
Article in Journal of the Royal Society, Interface, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 53 citations in OpenAlex.
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- Unraveling the pathogenesis and prevention strategies of acute high-altitude illness through gut microecology.NPJ biofilms and microbiomes · 2025Review
- Numerical investigation of new rete ridge formation in a multi-layer model of skin subjected to tissue expansion.Journal of biomechanics · 2024Article
- The role of interface geometry and appendages on the mesoscale mechanics of the skin.Biomechanics and modeling in mechanobiology · 2024Article
- Stem Cell Signaling Pathways in the Small Intestine.International journal of molecular sciences · 2020Review
- Post-buckling behaviour of a growing elastic rod.Journal of mathematical biology · 2019Article
- Chick midgut morphogenesis.The International journal of developmental biology · 2018Review
- Elastosis during airway wall remodeling explains multiple co-existing instability patterns.Journal of theoretical biology · 2016Article
- Patient-Specific Airway Wall Remodeling in Chronic Lung Disease.Annals of biomedical engineering · 2015Article
- On the mechanics of growing thin biological membranes.Journal of the mechanics and physics of solids · 2014Article
- On the Role of Mechanics in Chronic Lung Disease.Materials (Basel, Switzerland) · 2013Review
- Systems biology and mechanics of growth.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Villi are ubiquitous structures in the intestine of all vertebrates, originating from the embryonic development of the epithelial mucosa. Their morphogenesis has similar stages in living organisms but different forming mechanisms. In this work, we model the emergence of the bi-dimensional undulated patterns in the intestinal mucosa from which villi start to elongate. The embryonic mucosa is modelled as a growing thick-walled cylinder, and its mechanical behaviour is described using an hyperelastic constitutive model, which also accounts for the anisotropic characteristics of the reinforcing fibres at the microstructural level. The occurrence of surface undulations is investigated using a linear stability analysis based on the theory of incremental deformations superimposed on a finite deformation. The Stroh formulation of the incremental boundary value problem is derived, and a numerical solution procedure is implemented for calculating the growth thresholds of instability. The numerical results are finally discussed with respect to different growth and materials properties. In conclusion, we demonstrate that the emergence of intestinal villi in embryos is triggered by a differential growth between the mucosa and the mesenchymal tissues. The proposed model quantifies how both the geometrical and the mechanical properties of the mucosa drive the formation of previllous structures in embryos.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.