ArticleNature2013
The genomes of four tapeworm species reveal adaptations to parasitism.
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Article in Nature, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 371 papers, 1 of them a synthesis that pooled it.
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371citing papers in PubMed, 1 pooled it
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Who cites it
371 citing papers in PubMed, 1 synthesis or guideline pooled it, 812 citations in OpenAlex.
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- Discovery of new chromosomal markers through repeatome analysis of Caryophyllaeus laticeps (Caryophyllidea).Parasitology research · 2025Article
- Substantial Hierarchical Reductions of Genetic and Morphological Traits in the Evolution of Rotiferan Parasites.Genome biology and evolution · 2025Article
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311 more citing papers are in PubMed but not listed here.
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Authors and funding
53 authors at 19 institutions in 9 countries.
Isheng J Tsai *Parasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Magdalena Zarowiecki *Parasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Nancy Holroyd *Parasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Alejandro Garciarrubio *Institute of Biotechnology, Universidad Nacional Autónoma de México, 04510 México D.F., México.
Alejandro Sánchez-FloresParasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK; Institute of Biotechnology, Universidad Nacional Autónoma de México, 04510 México D.F., México.
Karen L BrooksParasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Alan TraceyParasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Raúl J BobesInstitute of Biomedical Research, Universidad Nacional Autónoma de México, 04510 México D.F., México.
Gladis FragosoInstitute of Biomedical Research, Universidad Nacional Autónoma de México, 04510 México D.F., México.
Edda SciuttoInstitute of Biomedical Research, Universidad Nacional Autónoma de México, 04510 México D.F., México.
Martin AslettParasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Helen BeasleyParasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Hayley M BennettParasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Xuepeng CaiState Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No 1, Xujiaping, Chengguan District, Lanzhou 730046, Gansu Province, China.
Federico CamiciaInstituto de Microbiología y Parasitología Médica, Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Tecnológicas (IMPaM, UBA-CONICET). Facultad de Medicina, Paraguay 2155, C1121ABG, Buenos Aires, Argentina.
Richard ClarkParasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Marcela CucherInstituto de Microbiología y Parasitología Médica, Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Tecnológicas (IMPaM, UBA-CONICET). Facultad de Medicina, Paraguay 2155, C1121ABG, Buenos Aires, Argentina.
Nishadi De SilvaParasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Tim A DayDepartment of Biomedical Sciences, Iowa State University, Ames, Iowa 50011, USA.
Peter DeplazesInstitute of Parasitology, Vetsuisse Faculty, University of Zürich, Winterthurerstrasse 266a, CH-8057 Zürich, Switzerland.
Karel EstradaInstitute of Biotechnology, Universidad Nacional Autónoma de México, 04510 México D.F., México.
Cecilia FernándezCátedra de Inmunologá, Facultad de Quámica, Universidad de la República. Av. Alfredo Navarro 3051, piso 2, Montevideo, CP 11600, Uruguay.
Peter W H HollandDepartment of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.
Junling HouState Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No 1, Xujiaping, Chengguan District, Lanzhou 730046, Gansu Province, China.
Songnian HuBeijing Institute of Genomics, Chinese Academy of Sciences, No.7 Beitucheng West Road, Chaoyang District, Beijing 100029, PR China.
Thomas HuckvaleParasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Stacy S HungDepartment of Biochemistry & Molecular and Medical Genetics, University of Toronto, Program in Molecular Structure & Function, The Hospital for Sick Children, Toronto, Ontario, Canada.
Laura KamenetzkyInstituto de Microbiología y Parasitología Médica, Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Tecnológicas (IMPaM, UBA-CONICET). Facultad de Medicina, Paraguay 2155, C1121ABG, Buenos Aires, Argentina.
Jacqueline A KeaneParasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Ferenc KissUniversity of Würzburg, Institute of Hygiene and Microbiology, Würzburg, Germany.
Uriel KoziolUniversity of Würzburg, Institute of Hygiene and Microbiology, Würzburg, Germany.
Olivia LambertParasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Kan LiuBeijing Institute of Genomics, Chinese Academy of Sciences, No.7 Beitucheng West Road, Chaoyang District, Beijing 100029, PR China.
Xuenong LuoState Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No 1, Xujiaping, Chengguan District, Lanzhou 730046, Gansu Province, China.
Yingfeng LuoBeijing Institute of Genomics, Chinese Academy of Sciences, No.7 Beitucheng West Road, Chaoyang District, Beijing 100029, PR China.
Natalia MacchiaroliInstituto de Microbiología y Parasitología Médica, Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Tecnológicas (IMPaM, UBA-CONICET). Facultad de Medicina, Paraguay 2155, C1121ABG, Buenos Aires, Argentina.
Sarah NicholParasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Jordi PapsDepartment of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.
John ParkinsonDepartment of Biochemistry & Molecular and Medical Genetics, University of Toronto, Program in Molecular Structure & Function, The Hospital for Sick Children, Toronto, Ontario, Canada.
Natasha Pouchkina-StantchevaDepartment of Life Sciences, The Natural History Museum, Cromwell Road, London SW7 5BD, UK.
Nick RiddifordDepartment of Life Sciences, The Natural History Museum, Cromwell Road, London SW7 5BD, UK; Department of Zoology, School of Natural Sciences and Regenerative Medicine Institute (REMEDI), National University of Ireland Galway, University Road, Galway, Ireland.
Mara RosenzvitInstituto de Microbiología y Parasitología Médica, Universidad de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Tecnológicas (IMPaM, UBA-CONICET). Facultad de Medicina, Paraguay 2155, C1121ABG, Buenos Aires, Argentina.
Gustavo SalinasCátedra de Inmunologá, Facultad de Quámica, Universidad de la República. Av. Alfredo Navarro 3051, piso 2, Montevideo, CP 11600, Uruguay.
James D WasmuthDepartment of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada.
Mostafa ZamanianInstitute of Parasitology, McGill University, 2111 Lakeshore Road, Ste. Anne de Bellevue, Quebec, H9X 3V9. Canada.
Yadong ZhengState Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No 1, Xujiaping, Chengguan District, Lanzhou 730046, Gansu Province, China.
Taenia solium Genome Consortium
Jianping CaiState Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No 1, Xujiaping, Chengguan District, Lanzhou 730046, Gansu Province, China.
Xavier SoberónInstitute of Biotechnology, Universidad Nacional Autónoma de México, 04510 México D.F., México; National Institute of Genomic Medicine, Ministry of Health, 01900, México D.F., México.
Peter D OlsonDepartment of Life Sciences, The Natural History Museum, Cromwell Road, London SW7 5BD, UK.
Juan P LacletteInstitute of Biomedical Research, Universidad Nacional Autónoma de México, 04510 México D.F., México.
Klaus BrehmUniversity of Würzburg, Institute of Hygiene and Microbiology, Würzburg, Germany.
Matthew BerrimanParasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Wellcome Sanger Institute · GBUniversidad Nacional Autónoma de México · MXChinese Academy of Agricultural Sciences · CNConsejo Nacional de Investigaciones Científicas y Técnicas · ARNatural History Museum · GBUniversity of Würzburg · DEBeijing Institute of Genomics · CNLanzhou Veterinary Research Institute · CNUniversidad de la República · UYUniversity of Buenos Aires · ARUniversity of Oxford · GBChinese Academy of Sciences · CNIowa State University · USMcGill University · CANational Institute of Genomic Medicine · MXSickKids Foundation · CAUniversity of Calgary · CAUniversity of Toronto · CAUniversity of Zurich · CH
Funding
Novel targets and drugs for the control of platyhelminth infectionsR03TW008588 · FIC · FUNDAQUIM · PI SALINAS, MARCOS GUSTAVO · 2010 to 2012
$129kBiotechnology and Biological Sciences Research Council BB/G003815/1Biotechnology and Biological Sciences Research Council BBG0038151CIHR MOP#84556FIC NIH HHS TW008588Wellcome Trust 085775Wellcome Trust 098051
Abstract
Tapeworms (Cestoda) cause neglected diseases that can be fatal and are difficult to treat, owing to inefficient drugs. Here we present an analysis of tapeworm genome sequences using the human-infective species Echinococcus multilocularis, E. granulosus, Taenia solium and the laboratory model Hymenolepis microstoma as examples. The 115- to 141-megabase genomes offer insights into the evolution of parasitism. Synteny is maintained with distantly related blood flukes but we find extreme losses of genes and pathways that are ubiquitous in other animals, including 34 homeobox families and several determinants of stem cell fate. Tapeworms have specialized detoxification pathways, metabolism that is finely tuned to rely on nutrients scavenged from their hosts, and species-specific expansions of non-canonical heat shock proteins and families of known antigens. We identify new potential drug targets, including some on which existing pharmaceuticals may act. The genomes provide a rich resource to underpin the development of urgently needed treatments and control.
Indexed as
Adaptation, PhysiologicalAnimalsBiological EvolutionCestodaCestode InfectionsConserved SequenceEchinococcus granulosusEchinococcus multilocularisGenes, HelminthGenes, HomeoboxGenome, HelminthHSP70 Heat-Shock ProteinsHumansHymenolepisMetabolic Networks and PathwaysMolecular Targeted TherapyHSP70 Heat-Shock ProteinsProteome
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