ReviewMolecular and cellular endocrinology2013
cAMP/PKA signaling defects in tumors: genetics and tissue-specific pluripotential cell-derived lesions in human and mouse.
Review in Molecular and cellular endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- PDE11A Is a Phenotype Modulator of Primary Bilateral Macronodular Adrenal Hyperplasia: Results of a 334-Patient Series.The Journal of clinical endocrinology and metabolism · 2025Article
- Protein kinase A and local signaling in cancer.The Biochemical journal · 2024Review
- Called and Uncalled for Functions of the Main Catalytic Subunit of Protein Kinase A: One Enzyme, Many Faces.Endocrinology · 2019Article
- Article
- Inflammation and Metabolism in Cancer Cell-Mitochondria Key Player.Frontiers in oncology · 2019Review
- Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function.Human molecular genetics · 2017Article
- Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas.Scientific reports · 2017Article
- Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells.Translational cancer research · 2016Article
- Diagnosis and Clinical Genetics of Cushing Syndrome in Pediatrics.Endocrinology and metabolism clinics of North America · 2016Review
- The G protein Gαs acts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis.Cell cycle (Georgetown, Tex.) · 2016Review
- cAMP-specific PDE4 phosphodiesterases and AIP in the pathogenesis of pituitary tumors.Endocrine-related cancer · 2016Article
- Mouse models of adrenocortical tumors.Molecular and cellular endocrinology · 2016Review
- Cholesterol Biosynthesis and Trafficking in Cortisol-Producing Lesions of the Adrenal Cortex.The Journal of clinical endocrinology and metabolism · 2015Article
- In-vivo detection of binary PKA network interactions upon activation of endogenous GPCRs.Scientific reports · 2015Article
- Germline PRKACA amplification causes variable phenotypes that may depend on the extent of the genomic defect: molecular mechanisms and clinical presentations.European journal of endocrinology · 2015Article
- Impact of kinase activating and inactivating patient mutations on binary PKA interactions.Frontiers in pharmacology · 2015Article
- Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer.Frontiers in pharmacology · 2015Article
- Phosphodiesterases and adrenal Cushing in mice and humans.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2014Review
- E pluribus unum? The main protein kinase A catalytic subunit (PRKACA), a likely oncogene, and cortisol-producing tumors.The Journal of clinical endocrinology and metabolism · 2014Article
- Carney complex and McCune Albright syndrome: an overview of clinical manifestations and human molecular genetics.Molecular and cellular endocrinology · 2014Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
In the last few years, bench and clinical studies led to significant new insight into how cyclic adenosine monophosphate (cAMP) signaling, the molecular pathway that had been identified in the early 2000s as the one involved in most benign cortisol-producing adrenal hyperplasias, affects adrenocortical growth and development, as well as tumor formation. A major discovery was the identification of tissue-specific pluripotential cells (TSPCs) as the culprit behind tumor formation not only in the adrenal, but also in bone. Discoveries in animal studies complemented a number of clinical observations in patients. Gene identification continued in parallel with mouse and other studies on the cAMP signaling and other pathways.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.