Trial reportBioMed research international2013
Association between inflammatory marker, environmental lead exposure, and glutathione S-transferase gene.
Trial report in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 77 citations in OpenAlex.
- Potential Antidote Against Lead Toxicity-A Review.International journal of molecular sciences · 2026Review
- Association between heavy metal exposure and high-sensitivity C-reactive protein in the elderly: Korea National Health and Nutrition Examination Survey (KNHANES) 2016-2017.Annals of occupational and environmental medicine · 2026Article
- Blood Lead Concentrations and Depressive and Anxiety Symptoms in Childhood.JAMA network open · 2026Article
- Clinical association between trace elements of tear and dry eye metrics.Scientific reports · 2022Article
- Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical Exposures.Current environmental health reports · 2022Review
- Article
- Glutathione S-transferase gene polymorphisms in association with susceptibility to lead toxicity in lead- and cadmium-exposed children near an abandoned lead-zinc mining area in Kabwe, Zambia.Environmental science and pollution research international · 2022Article
- Glutathione S-transferase, catalase, and mitochondrial superoxide dismutase gene polymorphisms modulate redox potential in systemic lupus erythematosus patients from Manaus, Amazonas, Brazil.Clinical rheumatology · 2021Article
- Association between cumulative childhood blood lead exposure and hepatic steatosis in young Mexican adults.Environmental research · 2021Article
- Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Effects ofAntioxidants (Basel, Switzerland) · 2020Article
- Identification of environmental chemicals targeting miscarriage genes and pathways using the comparative toxicogenomics database.Environmental research · 2020Article
- Article
- Curcumin Ameliorates Lead-Induced Hepatotoxicity by Suppressing Oxidative Stress and Inflammation, and Modulating Akt/GSK-3β Signaling Pathway.Biomolecules · 2019Article
- A Review of Biomonitoring of Phthalate Exposures.Toxics · 2019Review
- Serum endocan level and diastolic functions in the case of lead exposureTurkish journal of medical sciences · 2019Article
- Evaluation of Erectile Dysfunction and Left Ventricular Diastolic Parameters in Lead Exposed Workers.Acta Cardiologica Sinica · 2019Article
- Cardiovascular-Related Outcomes in U.S. Adults Exposed to Lead.International journal of environmental research and public health · 2018Article
- Vitamin D alleviates lead induced renal and testicular injuries by immunomodulatory and antioxidant mechanisms in rats.Scientific reports · 2018Article
- Childhood Lead Exposure and Adult Neurodegenerative Disease.Journal of Alzheimer's disease : JAD · 2018Review
- Effects of Hair Metals on Body Weight in Iranian Children Aged 20 to 36 Months.Iranian journal of public health · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of studies suggested that lead is related to the induction of oxidative stress, and alteration of immune response. In addition, modifying these toxic effects varied partly by GST polymorphism. The objectives of this study were to assess the association between the lead-induced alteration in serum hs-CRP, with GSTM1, GSTT1, and GSTP1 Val105Ile genetic variations and the health consequence from environmental lead exposure. The 924 blood samples were analyzed for blood lead, CRP, and genotyping of three genes with real-time PCR. Means of blood lead and serum hs-CRP were 5.45 μ g/dL and 2.07 mg/L. Both CRP and systolic blood pressure levels were significantly higher for individuals with blood lead in quartile 4 (6.48-24.63 μ g/dL) compared with those in quartile 1 (1.23-3.47 μ g/dL, P < 0.01). In particular, in men with blood lead >6.47 μ g/dL the adjusted odds ratio (OR) of CRP levels for individuals with GSTP1 variants allele, GSTM1 null, GSTT1 null, double-null GSTM1, and GSTT1 compared with wild-type allele was 1.46 (95% CI; 1.05-2.20), 1.32 (95% CI; 1.03-1.69), 1.65 (95% CI; 1.17-2.35), and 1.98 (95% CI; 1.47-2.55), respectively. Our findings suggested that lead exposure is associated with adverse changes in inflammatory marker and SBP. GST polymorphisms are among the genetic determinants related to lead-induced inflammatory response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.