ArticlePloS one2013
Detection and validation of circulating endothelial cells, a blood-based diagnostic marker of acute myocardial infarction.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- The role of polysaccharide peptide of Ganoderma lucidum as a potent antioxidant against atherosclerosis in high risk and stable angina patients.Indian heart journalTrial
- Comparison of HIF-1α and survivin levels in patients with diabetes and retinopathy of varying severity.Arquivos brasileiros de oftalmologia · 2024Article
- Endothelial-Related Biomarkers in Evaluation of Vascular Function During Progression of Sepsis After Severe Trauma: New Potential Diagnostic Tools in Sepsis.Journal of inflammation research · 2023Article
- AMBRA1 attenuates the proliferation of uveal melanoma cells.Open medicine (Warsaw, Poland) · 2022Article
- Ubiquitination of p21 by E3 Ligase TRIM21 Promotes the Proliferation of Human Neuroblastoma Cells.Neuromolecular medicine · 2021Article
- Coronary microvascular injury in myocardial infarction: perception and knowledge for mitochondrial quality control.Theranostics · 2021Review
- Article
- Circulating endothelial cells as biomarker for cardiovascular diseases.Research and practice in thrombosis and haemostasis · 2019Article
- Circulating Proangiogenic Cells and Proteins in Patients with Glioma and Acute Myocardial Infarction: Differences in Neovascularization between Neoplasia and Tissue Regeneration.Journal of oncology · 2019Article
- Insights into Endothelial Progenitor Cells: Origin, Classification, Potentials, and Prospects.Stem cells international · 2018Review
- A Whole Blood Molecular Signature for Acute Myocardial Infarction.Scientific reports · 2017Article
- Enumeration of circulating endothelial cell frequency as a diagnostic marker in aortic valve surgery - a flow cytometric approach.Journal of cardiothoracic surgery · 2017Article
- Treatment with retinoic acid and lens epithelial cell-conditioned mediumExperimental and therapeutic medicine · 2015Article
- Survivin contributes to the progression of diabetic retinopathy through HIF-1α pathway.International journal of clinical and experimental pathology · 2015Article
- Fluid phase biopsy for detection and characterization of circulating endothelial cells in myocardial infarction.Physical biology · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCirculating endothelial cells (CECs) are markers of vascular damage that have clinical relevance in many diseases, including acute myocardial infarction (AMI), and may be predictors of treatment responses. Herein, we investigated the diagnostic and prognostic value of CEC monitoring in AMI patients and a murine model. METHODOLOGY/PRINCIPAL
findingsCECs were defined as Hoechst 33342(+)/CD45(-/)CD31(+)/CD146(+)/CD133(-) in human blood samples and Hoechst 33342(+)/CD45(-/)CD31(+)/KDR(+)/CD117(-) in murine samples. To evaluate the validity and variability of our CEC detection system, peripheral blood samples of vascular endothelial growth factor-treated athymic nude mice and AMI patients were collected and subjected to intra-assay analysis. CEC detection by flow cytometry and real-time PCR were compared. Blood samples were obtained from 61 AMI patients, 45 healthy volunteers and 19 samples of the original AMI patients accepted one month treatment, via flow cytometry and expressed as a percentage of peripheral blood mononuclear cells.
resultsOur CEC detection method was validated and had limited variability. CEC concentrations were higher in AMI patients compared to healthy controls. One month post-treatment, CECs levels decreased significantly. CONCLUSIONS/SIGNIFICANCE: CEC levels may be useful as a diagnostic and prognostic biomarker in AMI patients.
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