ArticlePloS one2013
Reduction in adiposity, β-cell function, insulin sensitivity, and cardiovascular risk factors: a prospective study among Japanese with obesity.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Association between total, regional and organ fat and type 2 diabetes risk factors among Latino youth: A longitudinal study.Pediatric obesity · 2025Trial
- Change in CT-measured abdominal subcutaneous and visceral but not thigh fat areas predict future insulin sensitivity.Diabetes research and clinical practice · 2019Article
- PPAR-α Agonist Fenofibrate Reduces Insulin Resistance in Impaired Glucose Tolerance Patients with Hypertriglyceridemia: A Cross-Sectional Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2017Article
- High hemoglobin A1c levels within the non-diabetic range are associated with the risk of all cancers.International journal of cancer · 2016Article
- CVD-predictive performances of "a body shape index" versus simple anthropometric measures: Tehran lipid and glucose study.European journal of nutrition · 2016Article
- Visceral fat area is associated with HbA1c but not dialysate-related glucose load in nondiabetic PD patients.Scientific reports · 2015Article
- Effects of exenatide in a morbidly obese patient with type 2 diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2014Article
- Empirical change in the prevalence of overweight and obesity in adolescents from 2007 to 2011 in Guangzhou, China.European journal of pediatrics · 2014Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA reduction in adiposity may be associated with an improvement in insulin sensitivity and β-cell function as well as cardiovascular disease (CVD) risk factors; however, few studies have investigated these associations in a longitudinal setting.
methodsTo investigate these associations over a 1-year period, we conducted an observational analysis of 196 Japanese subjects with obesity in the Saku Control Obesity Program. We investigated the relations between changes in adiposity (body mass index [BMI], waist circumference, subcutaneous fat area [SFAT], and visceral fat area [VFAT]) and changes in HbA1c, fasting plasma glucose (FPG), insulin sensitivity index (ISI), the homeostasis model assessment β cell function (HOMA-β), lipids, and blood pressure.
resultsAll adiposity changes were positively associated with HbA1c and FPG changes. Reductions in BMI and VFAT were associated with HOMA-β reduction. Reductions in all adiposity measures were associated with an improvement in the ISI. Changes in most adiposity measures were positively associated with changes in blood pressure and lipid levels, except for LDL.
conclusionThe present findings provide additional supportive evidence indicating that a reduction in adiposity may lead to an improvement in insulin sensitivity and the reduction of CVD risk factors in obese individuals.
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