SynthesisPloS one2013
The effects of calcium channel blockers in the prevention of stroke in adults with hypertension: a meta-analysis of data from 273,543 participants in 31 randomized controlled trials.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 7 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- S-1 and 5-Fluorouracil-related adverse events in patients with advanced gastric cancer: A meta-analysis.PloS one · 2023Pooled it
- Calcium channel blockers versus other classes of drugs for hypertension.The Cochrane database of systematic reviews · 2022Pooled it
- Calcium channel blockers versus other classes of drugs for hypertension.The Cochrane database of systematic reviews · 2021Pooled it
- Profiling cerebrovascular function in migraine: A systematic review and meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Pooled it
- Practical clinical trials in psychopharmacology: a systematic review.Journal of clinical psychopharmacology · 2015Pooled it
- Calcium channel blocker compared with angiotensin receptor blocker for patients with hypertension: a meta-analysis of randomized controlled trials.Journal of clinical hypertension (Greenwich, Conn.) · 2014Pooled it
- Pooled it
- Association of a CCB-Related Pharmacogenomics-Guided Strategy with Blood Pressure Outcomes and Short-Term Safety in Chinese Patients with Hypertension: A Secondary Exploratory Analysis of Two Randomized Cohorts.Drug, healthcare and patient safety · 2026Article
- Update of the Korean Clinical Practice Guidelines for Stroke: Blood Pressure Management.Journal of clinical neurology (Seoul, Korea) · 2025Review
- Article
- The Evolving Role of Calcium Channel Blockers in Hypertension Management: Pharmacological and Clinical Considerations.Current issues in molecular biology · 2024Review
- Secondary Ischemic Stroke Prevention.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Neuroprotective effects of anExperimental and therapeutic medicine · 2022Article
- Efonidipine Exerts Cerebroprotective Effect by Down-regulation of TGF-β/SMAD-2-Dependent Signaling Pathway in Diabetic Rats.Journal of molecular neuroscience : MN · 2021Article
- Effect of Sociodemographic Factors, Concomitant Disease States, and Measures Performed in the Emergency Department on Patient Disability in Ischemic Stroke: Retrospective Study from Lebanon.Stroke research and treatment · 2021Article
- Blood pressure lowering and stroke prevention: a systematic review and network meta-analysis protocol.Annals of translational medicine · 2019Article
- 2018 Korean society of hypertension guidelines for the management of hypertension: part III-hypertension in special situations.Clinical hypertension · 2019Article
- Choices for long-term hypertensive control in patients after first-ever hemorrhagic stroke: a nationwide cohort study.Therapeutic advances in neurological disorders · 2018Article
- Stroke Risk Factors, Genetics, and Prevention.Circulation research · 2017Review
- New generations of dihydropyridines for treatment of hypertension.Journal of geriatric cardiology : JGC · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertension is a major risk factor for the development of stroke. It is well known that lowering blood pressure decreases the risk of stroke in people with moderate to severe hypertension. However, the specific effects of calcium channel blockers (CCBs) against stroke in patients with hypertension as compared to no treatment and other antihypertensive drug classes are not known. METHODS AND
findingsThis systematic review and meta-analysis of randomized controlled trials (RCTs) evaluated CCBs effect on stroke in patients with hypertension in studies of CCBs versus placebo, angiotensin-converting-enzyme inhibitors (ACEIs), β-adrenergic blockers, and diuretics. The PUBMED, MEDLINE, EMBASE, OVID, CNKI, MEDCH, and WANFANG databases were searched for trials published in English or Chinese during the period January 1, 1996 to July 31, 2012. A total of 177 reports were collected, among them 31 RCTs with 273,543 participants (including 130,466 experimental subjects and 143,077 controls) met the inclusion criteria. In these trials a total of 9,550 stroke events (4,145 in experimental group and 5,405 in control group) were reported. CCBs significantly decreased the incidence of stroke compared with placebo (OR = 0.68, 95% CI 0.61-0.75, p<1×10(-5)), β-adrenergic blockers combined with diuretics (OR = 0.89, 95% CI 0.83-0.95, p = 7×10(-5)) and β-adrenergic blockers (OR = 0.79, 95% CI 0.72-0.87, p<1×10(-5)), statistically significant difference was not found between CCBs and ACEIs (OR = 0.92, 95% CI 0.8-1.02, p = 0.12) or diuretics (OR = 0.95, 95% CI 0.84-1.07, p = 0.39).
conclusionIn a pooled analysis of data of 31 RCTs measuring the effect of CCBs on stroke, CCBs reduced stroke more than placebo and β-adrenergic blockers, but were not different than ACEIs and diuretics. More head to head RCTs are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.