Trial reportPloS one2013
Enhanced stimulus-induced gamma activity in humans during propofol-induced sedation.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- The effects of AMPA receptor blockade on resting magnetoencephalography recordings.Journal of psychopharmacology (Oxford, England) · 2017Trial
- Resting GABA and glutamate concentrations do not predict visual gamma frequency or amplitude.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Beta power as a neural correlate of sensory features in autistic individuals.Journal of neurodevelopmental disorders · 2026Article
- Neurochemical-hemodynamic-electrophysiological coupling in the neonatal brain: a multimodal MRS-fMRI-EEG investigation.Frontiers in neuroscience · 2026Article
- Measuring the neurodevelopmental trajectory of excitatory-inhibitory balance via visual gamma oscillations.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Propofol-mediated Unconsciousness Disrupts Progression of Sensory Signals through the Cortical Hierarchy.Journal of cognitive neuroscience · 2024Article
- The acute effects of psychoactive drugs on emotional episodic memory encoding, consolidation, and retrieval: A comprehensive review.Neuroscience and biobehavioral reviews · 2023Review
- Individual/Peak Gamma Frequency: What Do We Know?Brain sciences · 2023Review
- From mechanisms to markers: novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans.Translational psychiatry · 2022Review
- Article
- Tiagabine induced modulation of oscillatory connectivity and activity match PET-derived, canonical GABA-A receptor distributions.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2021Article
- Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine.NeuroImage · 2020Article
- A multimodal magnetoencephalography 7 T fMRI and 7 T proton MR spectroscopy study in first episode psychosis.NPJ schizophrenia · 2020Article
- Effects of Transcranial Magnetic Stimulation Therapy on Evoked and Induced Gamma Oscillations in Children with Autism Spectrum Disorder.Brain sciences · 2020Article
- Anesthesia-induced loss of consciousness disrupts auditory responses beyond primary cortex.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Possible neurotoxicity of the anesthetic propofol: evidence for the inhibition of complex II of the respiratory chain in area CA3 of rat hippocampal slices.Archives of toxicology · 2018Article
- Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers.Journal of visualized experiments : JoVE · 2018Article
- On the Physiological Modulation and Potential Mechanisms Underlying Parieto-Occipital Alpha Oscillations.Frontiers in computational neuroscience · 2018Review
- Evaluation of short interval cortical inhibition and intracortical facilitation from the dorsolateral prefrontal cortex in patients with schizophrenia.Scientific reports · 2017Article
- Automatic inhibitory function in the human somatosensory and motor cortices: An MEG-MRS study.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stimulus-induced gamma oscillations in the 30-80 Hz range have been implicated in a wide number of functions including visual processing, memory and attention. While occipital gamma-band oscillations can be pharmacologically modified in animal preparations, pharmacological modulation of stimulus-induced visual gamma oscillations has yet to be demonstrated in non-invasive human recordings. Here, in fifteen healthy humans volunteers, we probed the effects of the GABAA agonist and sedative propofol on stimulus-related gamma activity recorded with magnetoencephalography, using a simple visual grating stimulus designed to elicit gamma oscillations in the primary visual cortex. During propofol sedation as compared to the normal awake state, a significant 60% increase in stimulus-induced gamma amplitude was seen together with a 94% enhancement of stimulus-induced alpha suppression and a simultaneous reduction in the amplitude of the pattern-onset evoked response. These data demonstrate, that propofol-induced sedation is accompanied by increased stimulus-induced gamma activity providing a potential window into mechanisms of gamma-oscillation generation in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.