ArticleMaedica2012
Hormonal and cytokine implications in the pathophysiology of osteoporosis occurring in chronic liver diseases.
Article in Maedica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Adefovir dipivoxil induced hypophosphatemic osteomalacia in chronic hepatitis B: a comparative study of Chinese and foreign case series.BMC pharmacology & toxicology · 2018Article
- Associations of TNF-α and IL-6 polymorphisms with osteoporosis through joint effects and interactions with LEPR gene in Taiwan: Taichung Community Health Study for Elders (TCHS-E).Molecular biology reports · 2016Article
- Osteoporosis across chronic liver disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
in the last years there has been an increased awareness regarding the alterations of bone metabolism as a common complication of chronic liver that occurs regardless of the etiologyalcoholic, viral, autoimmune, whether or not associated with cholestasis.The aim of this paper was to summarize the current understanding of bone metabolism and to point out the new discoveries that have been made in this field.Bone density is maintained constant due to the equilibrium between bone formation bone resorbtion, under the control of hormonal and proinflammatory cytokines. The influence of sex hormones, parathyroid hormone, growth hormone, and insulin-like growth factor-1 and 2 on bone metabolism is discussed. The role of proinflammatory cytokines, CSF1-RANKL system, leptin and oncofetal fibronectin are also discussed.Although the physiological mechanism of bone metabolism has been established, when it comes to pathological conditions, the hormones and cytokines have different new roles, or are associated with other factors having different influences.
Identifiers
23483875PMC3593291W52764242What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.