Evidence map›Paper›PMID 23483833›Full record

ArticleGastroenterology & hepatology2012

New developments in extraesophageal reflux disease.

Elif Saritas Yuksel, Michael F Vaezi

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Gastroenterology & hepatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02274636 (Study of a Dietary Supplement for Reflux During Sleep), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02274636 naunknown statusnot on this mapstarted 2014, after this paper: background citation

Study of a Dietary Supplement for Reflux During Sleep

TypeinterventionalSponsorOral Care Research Associates, SeattleRan2014 to 2016Enrolled50ConditionsGERDArmsXylitol
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Alginates and laryngopharyngeal reflux: where we stand. A systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Pooled it
  2. Trial
  3. Clinical Manifestations and Treatment Outcome of Laryngopharyngeal Reflux on Larynx and Symptom-Sign Correlation.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  4. Article
  5. Laryngopharyngeal Reflux Disease - LPRD.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2017
    Article
  6. Article
  7. Laparoscopic antireflux surgery in patients with extra esophageal symptoms related to asthma.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elif Saritas YukselDr. Saritas Yuksel is a Research Assistant in the Division of Gastroenterology, Hepatology, and Nutrition at Vanderbilt University Medical Center in Nashville, Tennessee. Dr. Vaezi is a Professor of Medicine; Clinical Director of the Division of Gastroenterology, Hepatol-ogy, and Nutrition; and Director of the Center for Swallowing and Esophageal Disorders, all at Vanderbilt University Medical Center.
Michael F Vaezi
Vanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastroesophageal reflux disease (GERD) can present with a wide variety of extraesophageal symptoms that are usually difficult to diagnose because of the absence of typical GERD symptoms (ie, regurgitation or heartburn). The diagnostic process is further complicated by the lack of a definitive test for identifying GERD as the cause of extraesophageal reflux symptoms. Due to the low predictive value of upper endoscopy and pH testing-as well as the lack of reliability of the symptom index and symptom association probability-extraesophageal reflux disease is still an area of investigation. This paper discusses recent developments in this field, with special emphasis on new diagnostic modalities and treatment options.

Indexed as

asthmachronic coughchronic laryngitisExtraesophageal reflux disease

Identifiers

PMID23483833
PMCPMC3594960
OpenAlexW2284064960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.