ArticleMedical journal of the Islamic Republic of Iran2012
The frequency of latent prostate carcinoma in autopsies of over 50 years old males, the Iranian experience.
Article in Medical journal of the Islamic Republic of Iran, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Prevalence of incidental prostate cancer: A systematic review of autopsy studies.International journal of cancer · 2015Pooled it
- Review
- Overexpression of TPX2 is associated with progression and prognosis of prostate cancer.Oncology letters · 2018Article
- Temporal trends and racial disparities in global prostate cancer prevalence.The Canadian journal of urology · 2014Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundLatent adenocarcinoma of prostate refers to cases who present no obvious sign or symptom during their life spans and the tumor is incidentally found at postmortem examination. Its frequency can be very important in epidemiologic investigations, prevention and treatment. No previous study has been done in this regard in Iran and the studies performed in other countries show various results. The aim of present study is to determine the frequency of latent prostate carcinoma by studying the corpora of men above 50 years old referred to forensic medicine organization in Tehran in 2008 and 2009.
methodsIn this study, 149 men aged above 50 who had died of different reasons and undergone autopsy were examined. Their prostates were excised and the slides were studied for the presence of adenocarcioma and prostatic intraepithelial neoplasia (PIN). In each case, age, weight of prostate, location of lesion, and grading according to Gleason's system were determined and the results were analyzed by SPSS software (version 16).
resultsOut of 149 cases, 34(22.8%) had low grade PIN, 26(17.4%) high grade PIN, and 14(9.4%) invasive adenocarcinoma. Most of the tumors were located in posterior lobe of prostate and they were more frequent in older cases (>65 years of age) and heavier prostates (p value <0.05). All invasive adenocarciomas were accompanied by PIN.
conclusionWorldwide studies show lower prevalence of latent carcinoma of prostate in Asian men than white European ones. Considering the absence of such studies in Iran, a larger study to compare and find out the precise rate of this kind of carcinoma, is recommended.
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23483598PMC3587897W1481820275What OpenQuestion holds
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