ArticleJournal of cachexia, sarcopenia and muscle2013
Investigation of changes in body composition, metabolic profile and skeletal muscle functional capacity in ischemic stroke patients: the rationale and design of the Body Size in Stroke Study (BoSSS).
Article in Journal of cachexia, sarcopenia and muscle, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04923165 (Influence of Nutritional Status on Rehabilitation Outcome in Subacute Stroke Patients), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Nutritional Status on Rehabilitation Outcome in Subacute Stroke Patients
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Nutritional therapy for reducing disability and improving activities of daily living in people after stroke.The Cochrane database of systematic reviews · 2024Pooled it
- Sympathetic nervous system-mediated fibro-adipogenic progenitor mobilization drives stroke-related sarcopenia.Cell discovery · 2026Article
- Accuracy of sarcopenia screening tools among older adults with stroke undergoing inpatient rehabilitation.PloS one · 2026Article
- Deep-learning-derived neuroimaging biomarkers of sarcopenia as predictors of outcome in endovascular thrombectomy in large vessel occlusion acute ischemic stroke.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Nutritional status in subacute post-stroke patients undergoing rehabilitation treatment: a protocol for a prospective observational study.BMC sports science, medicine & rehabilitation · 2025Article
- Investigating the causal relationship between genetically determined metabolites and ischemic stroke functional outcomes: a Mendelian randomization study.Cardiovascular diagnosis and therapy · 2025Article
- Stroke-Related Sarcopenia: Pathophysiology and Diagnostic Tools.Brain & NeuroRehabilitation · 2024Review
- Regimen on Dnaja3 haploinsufficiency mediated sarcopenic obesity with imbalanced mitochondrial homeostasis and lipid metabolism.Journal of cachexia, sarcopenia and muscle · 2024Article
- Pathophysiological changes of muscle after ischemic stroke: a secondary consequence of stroke injury.Neural regeneration research · 2024Review
- Article
- Iron Deficiency and Reduced Muscle Strength in Patients with Acute and Chronic Ischemic Stroke.Journal of clinical medicine · 2022Article
- The Effect of Branched Chain Amino Acid Supplementation on Stroke-Related Sarcopenia.Frontiers in neurology · 2022Article
- Ultrasound-Guided Median Nerve Electrical Stimulation to Promote Upper Limb Function Recovery after Stroke.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- An exploration of the prevalence and experience of cardiac cachexia: protocol for a mixed methods cross-sectional study.BMC palliative care · 2019Article
- Body weight changes and incidence of cachexia after stroke.Journal of cachexia, sarcopenia and muscle · 2019Observational
- Diet after Stroke and Its Impact on the Components of Body Mass and Functional Fitness-A 4-Month Observation.Nutrients · 2019Article
- Distinct Patterns of Fiber Type Adaptation in Rat Hindlimb Muscles 4 Weeks After Hemorrhagic Stroke.American journal of physical medicine & rehabilitation · 2019Article
- Sleep-Disordered Breathing in Acute Ischemic Stroke: A Mechanistic Link to Peripheral Endothelial Dysfunction.Journal of the American Heart Association · 2017Observational
- Searching for a relevant definition of sarcopenia: results from the cross-sectional EPIDOS study.Journal of cachexia, sarcopenia and muscle · 2016Article
- Evidence for partial pharmaceutical reversal of the cancer anorexia-cachexia syndrome: the case of anamorelin.Journal of cachexia, sarcopenia and muscle · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStroke is steadily increasing in prevalence. Muscle tissue wasting and functional changes are frequently observed in stroke, but this has not been studied in detail yet. There is a lack of data to support guideline recommendations on how to target muscle wasting in stroke patients. We hypothesise that pathophysiological metabolic profiles and muscle functional and structural impairment are developing in stroke patients, which are associated with stroke severity and outcome after stroke.
methodsThe Body Size in Stroke Study (BoSSS) is a prospective, longitudinal observation study that will explore associations between the metabolic profile, body tissue wasting and particular metabolic and functional changes in skeletal muscle tissue in stroke patients. Consecutive patients with acute stroke (n = 150) will be enrolled due to lacunar or territorial ischemic infarct in the area of the middle cerebral artery. Patients will be studied at annual intervals after 12 and 24 months. For comparison, healthy controls of similar age and patients with chronic heart failure will be used as control groups. The main objective is to study changes in body composition in stroke patients. Secondary, the study will focus on changes in insulin sensitivity of adipose tissue and skeletal muscle. Furthermore, measurements of endothelial function and peripheral blood flow will provide insight in the vascular regulation in stroke patients.
conclusionThis study will be the largest observational study providing insights into the metabolic and functional changes of muscle tissue in patients with acute ischemic stroke. The new data will increase our understanding of the pathophysiologic tissue wasting in stroke disease and help to develop new therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.