ArticleProtein & cell2013
Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling.
Article in Protein & cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Liquid-like condensates that bind actin promote assembly and bundling of actin filaments.Developmental cell · 2025Article
- Liquid-like condensates that bind actin drive filament polymerization and bundling.bioRxiv : the preprint server for biology · 2024Article
- PtdIns(3,4)P2, Lamellipodin, and VASP coordinate actin dynamics during phagocytosis in macrophages.The Journal of cell biology · 2022Article
- Phosphorylation of RIAM Activates Its Adaptor Function in Mediating Integrin Signaling.Journal of cellular signaling · 2021Article
- Initiation and disassembly of filopodia tip complexes containing VASP and lamellipodin.Molecular biology of the cell · 2020Article
- Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- TES functions as a Mena-dependent tumor suppressor in gastric cancer carcinogenesis and metastasis.Cancer communications (London, England) · 2019Article
- Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.Nature communications · 2017Article
- Grb7 protein RA domain oligomerization.Journal of molecular recognition : JMR · 2017Article
- Lamellipodin Is Important for Cell-to-Cell Spread and Actin-Based Motility in Listeria monocytogenes.Infection and immunity · 2015Article
- Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments.eLife · 2015Article
- Structural and mechanistic insights into the recruitment of talin by RIAM in integrin signaling.Structure (London, England : 1993) · 2014Article
- The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism.Journal of molecular cell biology · 2014Article
- Structural basis for the interaction of the adaptor protein grb14 with activated ras.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The adapter protein Lamellipodin (Lpd) plays an important role in cell migration. In particular, Lpd mediates lamellipodia formation by regulating actin dynamics via interacting with Ena/VASP proteins. Its RA-PH tandem domain configuration suggests that like its paralog RIAM, Lpd may also mediate particular Ras GTPase signaling. We determined the crystal structures of the Lpd RA-PH domains alone and with an N-terminal coiled-coil region (cc-RA-PH). These structures reveal that apart from the anticipated coiled-coil interaction, Lpd may also oligomerize through a second intermolecular contact site. We then validated both oligomerization interfaces in solution by mutagenesis. A fluorescence-polarization study demonstrated that Lpd binds phosphoinositol with low affinity. Based on our crystallographic and biochemical data, we propose that Lpd and RIAM serve diverse functions: Lpd plays a predominant role in regulating actin polymerization, and its function in mediating Ras GTPase signaling is largely suppressed compared to RIAM.
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